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Mia3 MIA SH3 domain ER export factor 3 [ Mus musculus (house mouse) ]

Gene ID: 338366, updated on 27-Nov-2024

Summary

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Official Symbol
Mia3provided by MGI
Official Full Name
MIA SH3 domain ER export factor 3provided by MGI
Primary source
MGI:MGI:2443183
See related
Ensembl:ENSMUSG00000056050 AllianceGenome:MGI:2443183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tango; Gm1525; TANGO1; 9130229H14Rik; A930039G15Rik; B230399H06Rik
Summary
Predicted to enable cargo receptor activity. Acts upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Located in endoplasmic reticulum membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart; nervous system; and nose. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 13.7), colon adult (RPKM 13.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mia3 in Genome Data Viewer
Location:
1; 1 H5
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183107091..183151091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183326236..183369565, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene axin interactor, dorsalization associated Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, A Neighboring gene hedgehog interacting protein-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration. Lei Y, et al. Front Endocrinol (Lausanne), 2021. PMID 34858331, Free PMC Article
  2. Characterization and expression pattern of the novel MIA homolog TANGO. Bosserhoff AK, et al. Gene Expr Patterns, 2004 Jul. PMID 15183315
  3. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
  4. Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Moser M, et al. Mol Cell Biol, 2002 Mar. PMID 11839810, Free PMC Article
  5. Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. Wilson DG, et al. J Cell Biol, 2011 May 30. PMID 21606205, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
    Title: MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.
  2. Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms
    Title: Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.
  3. revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family
    Title: Characterization and expression pattern of the novel MIA homolog TANGO.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0268

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in COPII-coated vesicle cargo loading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transport and Golgi organization protein 1 homolog
Names
melanoma inhibitory activity 3
melanoma inhibitory activity protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177389.4 → NP_796363.3  transport and Golgi organization protein 1 homolog precursor

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108037, AEKQ02108038, CAAA01083531
    UniProtKB/Swiss-Prot
    A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
    UniProtKB/TrEMBL
    A0A0R4J2D3
    Related
    ENSMUSP00000141268.4, ENSMUST00000194543.4
    Conserved Domains (4) summary
    PHA03247
    Location:1014 → 1144
    PHA03247; large tegument protein UL36; Provisional
    PRK14949
    Location:716 → 1119
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    TIGR02168
    Location:1241 → 1606
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    183107091..183151091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165968.1 → XP_036021861.1  transport and Golgi organization protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
    Conserved Domains (4) summary
    PHA03247
    Location:1014 → 1144
    PHA03247; large tegument protein UL36; Provisional
    PRK14949
    Location:716 → 1119
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    TIGR02168
    Location:1241 → 1606
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

  2. XM_036165967.1 → XP_036021860.1  transport and Golgi organization protein 1 homolog isoform X2

    UniProtKB/Swiss-Prot
    A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
    Conserved Domains (4) summary
    PHA03247
    Location:1014 → 1144
    PHA03247; large tegument protein UL36; Provisional
    PRK14949
    Location:716 → 1119
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    TIGR02168
    Location:1241 → 1606
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

  3. XM_036165966.1 → XP_036021859.1  transport and Golgi organization protein 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    A0JLX8, Q3UFI9, Q571D7, Q8BI84, Q8BJE9, Q8BL31, Q8C5B9
    Conserved Domains (4) summary
    PHA03247
    Location:1671 → 1954
    PHA03247; large tegument protein UL36; Provisional
    PRK14949
    Location:716 → 1119
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    TIGR04523
    Location:1239 → 1625
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

  4. XM_036165972.1 → XP_036021865.1  transport and Golgi organization protein 1 homolog isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:514 → 805
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:92 → 457
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06409
    Location:43 → 82
    NPIP; Nuclear pore complex interacting protein (NPIP)

  5. XM_036165973.1 → XP_036021866.1  transport and Golgi organization protein 1 homolog isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:522 → 781
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:92 → 457
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06409
    Location:43 → 82
    NPIP; Nuclear pore complex interacting protein (NPIP)

RNA

  1. XR_004942926.1 RNA Sequence

  2. XR_004942925.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI84.2 GenPept UniProtKB/Swiss-Prot:Q8BI84

Gene LinkOut

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