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Tsp26A Tetraspanin 26A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33838, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp26Aprovided by FlyBase
Official Full Name
Tetraspanin 26Aprovided by FlyBase
Primary source
FLYBASE:FBgn0031760
Locus tag
Dmel_CG9093
See related
AllianceGenome:FB:FBgn0031760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9093; Dm.Tsp26A; Dmel\CG9093; tsp26A
Summary
Involved in intracellular transport and positive regulation of Notch signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tsp26A in Genome Data Viewer
Location:
26B2-26B2; 2-18 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6000228..6003738)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6000228..6003738)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene infertile crescent Neighboring gene Lysine demethylase 5 Neighboring gene antisense RNA:CR43866 Neighboring gene beta galactosidase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
  2. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article
  3. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. Dornier E, et al. J Cell Biol, 2012 Oct 29. PMID 23091066, Free PMC Article
  4. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
  5. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin 26A
Names
CG9093-PB
CG9093-PC
CG9093-PD
Tsp26A-PB
Tsp26A-PC
Tsp26A-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6000228..6003738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103623.4 → NP_001097093.1  tetraspanin 26A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q32KF8, Q9VMJ6
    Conserved Domains (3) summary
    cd03159
    Location:118 → 239
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18 → 253
    Tetraspannin; Tetraspanin family
    cl19878
    Location:65 → 157
    DUF2207; Predicted membrane protein (DUF2207)

  2. NM_001273190.1 → NP_001260119.1  tetraspanin 26A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260119.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCP6, Q32KF8
    Conserved Domains (3) summary
    cd03159
    Location:118 → 239
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18 → 263
    Tetraspannin; Tetraspanin family
    cl19878
    Location:65 → 157
    DUF2207; Predicted membrane protein (DUF2207)

  3. NM_001258982.2 → NP_001245911.1  tetraspanin 26A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245911.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NCS1, Q32KF8
    Conserved Domains (3) summary
    cd03159
    Location:118 → 241
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18 → 265
    Tetraspannin; Tetraspanin family
    cl19878
    Location:65 → 157
    DUF2207; Predicted membrane protein (DUF2207)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NCS1 M9NCS1
M9PCP6 M9PCP6
Q9VMJ6 Q9VMJ6

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