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AANATL2 Arylalkylamine N-acetyltransferase-like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33874, updated on 9-Dec-2024

Summary

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Official Symbol
AANATL2provided by FlyBase
Official Full Name
Arylalkylamine N-acetyltransferase-like 2provided by FlyBase
Primary source
FLYBASE:FBgn0031791
Locus tag
Dmel_CG9486
See related
AllianceGenome:FB:FBgn0031791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aaNAT2; AANAT2; CG9486; DmAANATL2; Dmel\CG9486
Summary
Enables acyl-CoA N-acyltransferase activity and aralkylamine N-acetyltransferase activity. Is expressed in adult abdomen and adult thorax. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See AANATL2 in Genome Data Viewer
Location:
26C1-26C1; 2-19 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6255859..6256822)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6255859..6256822)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44823 Neighboring gene UDP-glycosyltransferase family 37 member B1 Neighboring gene Discoidin domain receptor Neighboring gene long non-coding RNA:CR46410 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster. Anderson RL, et al. Arch Insect Biochem Physiol, 2019 Dec. PMID 31385627, Free PMC Article
  2. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2. Dempsey DR, et al. Insect Biochem Mol Biol, 2015 Nov. PMID 26476413, Free PMC Article
  3. Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins. Dempsey DR, et al. FEBS Lett, 2014 Feb 14. PMID 24444601, Free PMC Article
  4. Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis. O'Flynn BG, et al. Front Mol Biosci, 2018. PMID 30094237, Free PMC Article
  5. Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. Amherd R, et al. DNA Cell Biol, 2000 Nov. PMID 11098219

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AANATL2 catalyzes the formation of N-acylarylalkylamides using either different catalytic residues or a different chemical mechanism relative to other D. melanogaster AANATL enzymes.
    Title: Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2.
  2. AANATL2 has a role in the biosynthetic formation of long-chain N-acylserotonins
    Title: Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables aralkylamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arylalkylamine N-acetyltransferase-like 2
Names
AANATL2-PA
AANATL2-PB
CG9486-PA
CG9486-PB
arylalkylamine N-acetyltransferase 2
arylalkylamine N-acyltransferase-like 2
NP_001285667.1
NP_609005.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6255859..6256822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298738.1 → NP_001285667.1  arylalkylamine N-acetyltransferase-like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285667.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V4G0, Q9VMG0
    Conserved Domains (1) summary
    pfam00583
    Location:81 → 178
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_135161.3 → NP_609005.1  arylalkylamine N-acetyltransferase-like 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V4G0, Q9VMG0
    Related
    FBpp0078873
    Conserved Domains (1) summary
    pfam00583
    Location:81 → 178
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMG0.1 Q9VMG0

Gene LinkOut

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