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Pez Pez [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33882, updated on 4-Jan-2025

Summary

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Official Symbol
Pezprovided by FlyBase
Official Full Name
Pezprovided by FlyBase
Primary source
FLYBASE:FBgn0031799
Locus tag
Dmel_CG9493
See related
AllianceGenome:FB:FBgn0031799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9493; Dmel\CG9493; dPez; PEZ; PTPD1
Summary
Involved in several processes, including R8 cell differentiation; positive regulation of hippo signaling; and positive regulation of inflammatory response to wounding. Located in apical part of cell and cell cortex. Is active in lamellipodium. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14) and PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pez in Genome Data Viewer
Location:
26C3-26C3; 2-19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6332881..6338671, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6332881..6338671, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Discoidin domain receptor Neighboring gene uncharacterized protein Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Cytochrome P450 reductase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Edwards K, et al. Gene, 2001 Sep 19. PMID 11587846
  2. The Hippo size control pathway--ever expanding. Lin JI, et al. Sci Signal, 2013 Jan 22. PMID 23354686
  3. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Wang C, et al. Nat Commun, 2015 Mar 27. PMID 25814387
  4. PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Campbell JS, et al. Curr Biol, 2021 Feb 22. PMID 33296680, Free PMC Article
  5. PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation. Guo P, et al. Science, 2024 Aug 9. PMID 39116228

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in R8 cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in R8 cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of inflammatory response to wounding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Pez
Names
CG9493-PA
CG9493-PB
Pez-PA
Pez-PB
pez

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6332881..6338671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273198.1 → NP_001260127.1  Pez, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3V3
    Conserved Domains (6) summary
    smart00295
    Location:26 → 230
    B41; Band 4.1 homologues
    cd00047
    Location:1009 → 1243
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:225 → 317
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00102
    Location:1007 → 1243
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam00373
    Location:114 → 230
    FERM_M; FERM central domain
    pfam09379
    Location:26 → 93
    FERM_N; FERM N-terminal domain

  2. NM_135169.3 → NP_609013.1  Pez, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609013.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3V3
    Related
    FBpp0078914
    Conserved Domains (6) summary
    smart00295
    Location:26 → 230
    B41; Band 4.1 homologues
    cd00047
    Location:1009 → 1243
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:225 → 317
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00102
    Location:1007 → 1243
    Y_phosphatase; Protein-tyrosine phosphatase
    pfam00373
    Location:114 → 230
    FERM_M; FERM central domain
    pfam09379
    Location:26 → 93
    FERM_N; FERM N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3V3 Q9V3V3

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