SLCO1B7 solute carrier organic anion transporter family member 1B7 (putative) [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLCO1B7provided by HGNC
Official Full Name: solute carrier organic anion transporter family member 1B7 (putative)provided by HGNC
Primary source: HGNC:HGNC:32934
See related: MIM:619875; AllianceGenome:HGNC:32934
Gene type: pseudo
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LST3; LST-3; OATP1B7; SLC21A21; LST-3TM12
Summary: Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
Expression: Low expression observed in reference dataset See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12p12.2

Annotation release	Status	Assembly	Chr	Location
109.20210226	latest, but not current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (21015696..21090106)

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
Title: circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
Title: Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
Results showed that OATP1B3-1B7 interacts with several drugs. One of the identified inhibitors was ezetimibe, which is also a substrate ofOATP1B3-1B7. Moreover, ezetimibe glucuronidation rates were decreased by bromsulphthalein, which is a OATP1B3-1B7 inhibitor. Thus, OATP1B3- 1B7 may function as a smooth endoplasmic reticulum gateway for ezetimibe.
Title: OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe.
This study investigated the expression and function of LST-3TM12 as a member of a multigene family.
Title: LST-3TM12 is a member of the OATP1B family and a functional transporter.
Observational study of gene-disease association. (HuGE Navigator)
Title: Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Markers

D12S1836 (e-PCR)
- UniSTS:68175

SLC21A8_826 (e-PCR)
- UniSTS:277731

RH68705 (e-PCR)
- UniSTS:60656

Potential readthrough

Included gene: SLCO1B3

Potential readthrough

Included gene: SLCO1B1

Readthrough SLCO1B3-SLCO1B7

Readthrough gene: SLCO1B3-SLCO1B7, Included gene: SLCO1B3

Homology

NCBI Orthologs

Other Names

liver-specific organic anion transporter 3
liver-specific organic anion transporter 3TM12
organic anion transporter LST-3b
putative solute carrier organic anion transporter family member 1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001009562.4: Suppressed sequence

Description

NM_001009562.4: This RefSeq was removed because it is now thought that this gene does not encode a protein.