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Cpr Cytochrome P450 reductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33883, updated on 9-Dec-2024

Summary

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Official Symbol
Cprprovided by FlyBase
Official Full Name
Cytochrome P450 reductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0015623
Locus tag
Dmel_CG11567
See related
AllianceGenome:FB:FBgn0015623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CCR; CG11567; cpr; CPR; DmCPR; Dmel\CG11567; DMR; NCPR; P450
Summary
Predicted to enable FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Involved in cuticle hydrocarbon biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult heart; embryonic/larval midgut primordium; epithelium; gut section; and organism subdivision. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cpr in Genome Data Viewer
Location:
26C3-26C3; 2-19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6338836..6346280)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6338836..6346280)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Pez Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene amplification and microsatellite polymorphism underlie a recent insect host shift. Bass C, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218582, Free PMC Article
  2. Drosophila melanogaster NADPH-cytochrome P450 oxidoreductase: pronounced expression in antennae may be related to odorant clearance. Hovemann BT, et al. Gene, 1997 Apr 21. PMID 9168130
  3. Differential metabolism of neonicotinoids by brown planthopper, Nilaparvata lugens, CYP6ER1 variants. Hamada A, et al. Pestic Biochem Physiol, 2020 May. PMID 32359560
  4. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Qiu Y, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927409, Free PMC Article
  5. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. Helvig C, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555597

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH-hemoprotein reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH-hemoprotein reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cuticle hydrocarbon biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system HDA PubMed 
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome P450 reductase
Names
CG11567-PA
CG11567-PB
CG11567-PC
CG11567-PD
Cpr-PA
Cpr-PB
Cpr-PC
Cpr-PD
NADPH--ferrihemoprotein reductase; NADPH-cytochrome P450 reductase
NADPH-cytochrome P450 oxidoreductase
NADPH-cytochrome P450 reductase
P450 reductase
cytochrome c reductase (NADPH)
NP_001260128.1
NP_001260129.1
NP_477158.1
NP_723173.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6338836..6346280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057810.4 → NP_477158.1  cytochrome P450 reductase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477158.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27597, Q9VMF2
    UniProtKB/TrEMBL
    A0A6C0PTF0, M9PCQ1
    Related
    FBpp0078880
    Conserved Domains (3) summary
    cd06204
    Location:281 → 678
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:80 → 678
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:86 → 223
    Flavodoxin_1; Flavodoxin

  2. NM_001273200.1 → NP_001260129.1  cytochrome P450 reductase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27597, Q9VMF2
    UniProtKB/TrEMBL
    A0A6C0PTF0, M9PCQ1
    Conserved Domains (3) summary
    cd06204
    Location:281 → 678
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:80 → 678
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:86 → 223
    Flavodoxin_1; Flavodoxin

  3. NM_001273199.1 → NP_001260128.1  cytochrome P450 reductase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260128.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27597, Q9VMF2
    UniProtKB/TrEMBL
    A0A6C0PTF0, M9PCQ1
    Conserved Domains (3) summary
    cd06204
    Location:281 → 678
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:80 → 678
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:86 → 223
    Flavodoxin_1; Flavodoxin

  4. NM_164689.2 → NP_723173.1  cytochrome P450 reductase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMD4, Q8IPJ7
    Related
    FBpp0078881
    Conserved Domains (3) summary
    cd06204
    Location:152 → 549
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:45 → 549
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:45 → 94
    Flavodoxin_1; Flavodoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCQ1 M9PCQ1
Q27597.2 Q27597
Q8IPJ7 Q8IPJ7

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