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COX5BL Cytochrome c oxidase subunit 5B-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33919, updated on 9-Dec-2024

Summary

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Official Symbol
COX5BLprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 5B-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0031831
Locus tag
Dmel_CG11043
See related
AllianceGenome:FB:FBgn0031831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11043; COXB; Dmel\CG11043; Vb
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial envelope. Is expressed in adult head and spermatozoon. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See COX5BL in Genome Data Viewer
Location:
26E3-26E3; 2-21 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6559431..6560133)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6559431..6560133)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene Dipeptidyl peptidase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
  2. Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the 91-R Strain of Drosophila melanogaster (Diptera: Drosophilidae). Steele LD, et al. J Insect Sci, 2018 Nov 1. PMID 30383265, Free PMC Article
  3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
  4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
  5. Two functionally different mitochondrial phosphate carriers support Drosophila melanogaster OXPHOS throughout distinct developmental stages. Curcio R, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37898376

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cytochrome c oxidase subunit 5B-like
Names
CG11043-PA
COX5BL-PA
cytochrome c oxidase polypeptide Vb

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6559431..6560133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135203.3 → NP_609047.1  cytochrome c oxidase subunit 5B-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMB8
    Related
    FBpp0078919
    Conserved Domains (1) summary
    cd00924
    Location:63 → 154
    Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMB8 Q9VMB8

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