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Trmt6 tRNA methyltransferase 6 non-catalytic subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33920, updated on 4-Jan-2025

Summary

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Official Symbol
Trmt6provided by FlyBase
Official Full Name
tRNA methyltransferase 6 non-catalytic subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0031832
Locus tag
Dmel_CG9596
See related
AllianceGenome:FB:FBgn0031832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9596; Dmel\CG9596; TRMT6
Summary
Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; foregut primordium; hindgut proper primordium; and larval muscle system. Used to study candidiasis. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Trmt6 in Genome Data Viewer
Location:
26E3-26E3; 2-21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6559426..6562289, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6559426..6562289, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene Dipeptidyl peptidase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
  2. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. Knight D, et al. J Neurosci, 2010 Apr 7. PMID 20371825, Free PMC Article
  3. Analysis of insect nuclear small heat shock proteins and interacting proteins. Moutaoufik MT, et al. Cell Stress Chaperones, 2021 Jan. PMID 32888179, Free PMC Article
  4. A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection. Glittenberg MT, et al. Dis Model Mech, 2022 May 1. PMID 35142345, Free PMC Article
  5. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA methyltransferase 6 non-catalytic subunit
Names
CG9596-PB
CG9596-PC
CG9596-PD
Trmt6-PB
Trmt6-PC
Trmt6-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6559426..6562289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298750.1 → NP_001285679.1  tRNA methyltransferase 6 non-catalytic subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS69
    Conserved Domains (1) summary
    pfam04189
    Location:9 → 309
    Gcd10p; Gcd10p family

  2. NM_135204.3 → NP_609048.2  tRNA methyltransferase 6 non-catalytic subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609048.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS69
    Conserved Domains (1) summary
    pfam04189
    Location:9 → 309
    Gcd10p; Gcd10p family

  3. NM_205916.2 → NP_995638.1  tRNA methyltransferase 6 non-catalytic subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995638.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS69
    Conserved Domains (1) summary
    pfam04189
    Location:9 → 309
    Gcd10p; Gcd10p family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS69 Q8MS69

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