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DIP-iota Dpr-interacting protein iota [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33925, updated on 9-Dec-2024

Summary

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Official Symbol
DIP-iotaprovided by FlyBase
Official Full Name
Dpr-interacting protein iotaprovided by FlyBase
Primary source
FLYBASE:FBgn0031837
Locus tag
Dmel_CG11320
See related
AllianceGenome:FB:FBgn0031837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11320; CG11320; CT31597; DIPiota; Dmel\CG11320
Summary
Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See DIP-iota in Genome Data Viewer
Location:
26F1-26F3; 2-21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6617134..6621700, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6617134..6621700, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dipeptidyl peptidase 10 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44913 Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 26F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article
  2. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Wang Y, et al. Development, 2022 May 15. PMID 35502740, Free PMC Article
  3. Neuronal Wiring Receptors Dprs and DIPs Are GPI Anchored and This Modification Contributes to Their Cell Surface Organization. Lobb-Rabe M, et al. eNeuro, 2024 Feb. PMID 38233143, Free PMC Article
  4. Computational Assessment of Protein-Protein Binding Specificity within a Family of Synaptic Surface Receptors. Nandigrami P, et al. J Phys Chem B, 2022 Oct 6. PMID 35787023
  5. DIP/Dpr interactions and the evolutionary design of specificity in protein families. Sergeeva AP, et al. Nat Commun, 2020 May 1. PMID 32358559, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Dpr-interacting protein iota
Names
CG11320-PB
DIP-iota-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6617134..6621700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103630.2 → NP_001097100.1  Dpr-interacting protein iota [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097100.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3F0
    Conserved Domains (3) summary
    smart00408
    Location:245 → 313
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141 → 227
    IG_like; Immunoglobulin like
    cl11960
    Location:132 → 213
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V3F0 Q4V3F0

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