U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cort cortex [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33937, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
cortprovided by FlyBase
Official Full Name
cortexprovided by FlyBase
Primary source
FLYBASE:FBgn0000351
Locus tag
Dmel_CG11330
See related
AllianceGenome:FB:FBgn0000351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11330; cor; Cort; Dmel\CG11330
Summary
Enables anaphase-promoting complex binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; female meiotic nuclear division; and positive regulation of anaphase-promoting complex-dependent catabolic process. Located in cytoplasm. Is expressed in adult heart. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cort in Genome Data Viewer
Location:
26F7-26F7; 2-21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6674682..6676635, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6674682..6676635, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Galactose-1-phosphate uridylyltransferase Neighboring gene Serpin 27A Neighboring gene Non-SMC element 1 Neighboring gene Na[+]/H[+] hydrogen exchanger 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis. Schisa JA, et al. Development, 1998 Aug. PMID 9655821
  2. Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Swan A, et al. Cell Cycle, 2005 Oct. PMID 16138012
  3. Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Kronja I, et al. Proc Natl Acad Sci U S A, 2014 Nov 11. PMID 25349405, Free PMC Article
  4. The Drosophila genes grauzone and cortex are necessary for proper female meiosis. Page AW, et al. J Cell Sci, 1996 Jul. PMID 8832393
  5. Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein. Chen B, et al. Development, 2000 Mar. PMID 10683177

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data indicate APC(Cort) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.
    Title: A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.
  2. CORT physically associates with core subunits of the APC/C in ovaries. APC/C(CORT) targets Cyclin A for degradation prior to the metaphase I arrest, while Cyclins B and B3 are not targeted until after egg activation.
    Title: Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator.
  3. Cks30A interacts with Cdk1 to target cyclin A for destruction in the female germline, possibly through the activation of a novel germline specific CDC20 protein, Cortex
    Title: Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction.
  4. Cyclin B associates with spindle microtubules throughout meiosis I and meiosis II, and dissociates from the meiotic spindle in anaphase II. Fzy and Cort are required for this loss of cyclin B from the meiotic spindle.
    Title: The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables anaphase-promoting complex binding IEA
Inferred from Electronic Annotation
more info
  
enables anaphase-promoting complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellularization HMP PubMed 
involved_in egg activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiosis I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in female meiosis II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome segregation TAS
Traceable Author Statement
more info
 PubMed 
involved_in pole cell formation HMP PubMed 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cortex
Names
CG11330-PA
CG11330-PB
cdc20-like
cort-PA
cort-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6674682..6676635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078770.2 → NP_523494.1  cortex, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960N3, Q9VMA1
    UniProtKB/TrEMBL
    M9PCR0
    Related
    FBpp0078949
    Conserved Domains (3) summary
    COG2319
    Location:166 → 453
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:201 → 244
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:166 → 451
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001273215.1 → NP_001260144.1  cortex, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260144.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960N3, Q9VMA1
    UniProtKB/TrEMBL
    M9PCR0
    Conserved Domains (3) summary
    COG2319
    Location:166 → 453
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:201 → 244
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:166 → 451
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCR0 M9PCR0
Q960N3.2 Q960N3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools