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AkhR Adipokinetic hormone receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33942, updated on 4-Jan-2025

Summary

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Official Symbol
AkhRprovided by FlyBase
Official Full Name
Adipokinetic hormone receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0025595
Locus tag
Dmel_CG11325
See related
AllianceGenome:FB:FBgn0025595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AKH R; Akh-R; AKH-R; akhr; akhR; Akhr; AKHR; Akhr/GRHR; AkhR/GRHR; BEST:GH19447; CG11325; DAKHR; DAKHR-1; DGRHR; Dmel\CG11325; GnRHR; GRHR; GRHR/CG11325
Summary
Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including cellular response to starvation; glucose homeostasis; and triglyceride homeostasis. Located in membrane. Is expressed in adult fat body; adult head; adult subesophageal zone; embryonic/larval fat body; and gustatory receptor neurons. Used to study obesity. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to several human genes including GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AkhR in Genome Data Viewer
Location:
27A1-27A1; 2-22 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6711286..6716186, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6711286..6716186, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Thrombospondin Neighboring gene Apoptosis antagonizing transcription factor Neighboring gene homer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors for vertebrates. Hauser F, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731220
  2. Parental obesity leads to metabolic changes in the F2 generation in Drosophila. Palu RAS, et al. Mol Metab, 2017 Jul. PMID 28702320, Free PMC Article
  3. Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants. Gáliková M, et al. Genetics, 2015 Oct. PMID 26275422, Free PMC Article
  4. Dietary glucose regulates yeast consumption in adult Drosophila males. Lebreton S, et al. Front Physiol, 2014. PMID 25566097, Free PMC Article
  5. The Glucagon-Like Adipokinetic Hormone in Drosophila melanogaster - Biosynthesis and Secretion. Hughson BN. Front Physiol, 2021. PMID 35002748, Free PMC Article

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of ppk28 increased neuronal glucagon-like adipokinetic hormone (AKH) signaling, and the AKH receptor was necessary for ppk28 mutant effects.
    Title: Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.
  2. characterization of adipokinetic hormone receptor in insects
    Title: Discovery of a novel insect neuropeptide signaling system closely related to the insect adipokinetic hormone and corazonin hormonal systems.
  3. mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor, leads to abnormal accumulation of both lipid and carbohydrate.
    Title: A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis.
  4. important for chronic accumulation and acute mobilization of storage fat
    Title: Dual lipolytic control of body fat storage and mobilization in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables adipokinetic hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables adipokinetic hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
adipokinetic hormone receptor
Names
AKH receptor
AkhR-PA
AkhR-PB
AkhR-PC
AkhR-PD
CG11325-PA
CG11325-PB
CG11325-PC
CG11325-PD
Drm-AKH receptor-1
gonadotrophin-releasing hormone receptor
gonadotropin-releasing hormone receptor
hormone receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6711286..6716186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_205917.3 → NP_995639.1  adipokinetic hormone receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995639.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q71EB3, Q7KTL9
    Conserved Domains (1) summary
    pfam00001
    Location:55 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_058039.4 → NP_477387.1  adipokinetic hormone receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477387.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77152, Q9VM96
    Related
    FBpp0078938
    Conserved Domains (1) summary
    pfam00001
    Location:55 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_164705.3 → NP_723206.1  adipokinetic hormone receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77152, Q9VM96
    Related
    FBpp0078939
    Conserved Domains (1) summary
    pfam00001
    Location:55 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. NM_001273220.1 → NP_001260149.1  adipokinetic hormone receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260149.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77152, Q9VM96
    Conserved Domains (1) summary
    pfam00001
    Location:55 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77152 O77152
Q71EB3 Q71EB3
Q7KTL9 Q7KTL9
Q95T55 Q95T55
Q9VM96 Q9VM96

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