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homer homer [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33944, updated on 9-Dec-2024

Summary

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Official Symbol
homerprovided by FlyBase
Official Full Name
homerprovided by FlyBase
Primary source
FLYBASE:FBgn0025777
Locus tag
Dmel_CG11324
See related
AllianceGenome:FB:FBgn0025777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD03829; CG11324; dhom; Dhom; Dhomer; Dm Homer; Dmel\CG11324; Dvh; Hom; Homer; LD03829
Summary
Predicted to enable G protein-coupled glutamate receptor binding activity. Involved in behavioral response to ethanol; positive regulation of circadian sleep/wake cycle, sleep; and regulation of locomotion. Located in dendrite and endoplasmic reticulum. Is expressed in several structures, including brain; central nervous system; embryonic/larval midgut primordium; head epidermis primordium; and synaptic neuropil domain. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to several human genes including HOMER2 (homer scaffold protein 2) and HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See homer in Genome Data Viewer
Location:
27A1-27A1; 2-22 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6719394..6723359, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6719394..6723359, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adipokinetic hormone receptor Neighboring gene Apoptosis antagonizing transcription factor Neighboring gene Liprin-alpha Neighboring gene Tubulin tyrosine ligase-like 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. Urizar NL, et al. J Neurosci, 2007 Apr 25. PMID 17460067, Free PMC Article
  2. Role of Homer proteins in the maintenance of sleep-wake states. Naidoo N, et al. PLoS One, 2012. PMID 22532843, Free PMC Article
  3. Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila. Ly S, et al. Sleep, 2020 Jan 13. PMID 31418019, Free PMC Article
  4. Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila. Awofala AA. Invert Neurosci, 2011 Jun. PMID 21153676
  5. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack Y, et al. Nature, 2006 Jun 1. PMID 16511445

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homer
Names
CG11324-PA
CG11324-PB
CG11324-PD
CG11324-PE
CG11324-PF
CG11324-PG
d-Homer
drosophila Ves-1 homolog
homer-PA
homer-PB
homer-PD
homer-PE
homer-PF
homer-PG
NP_001260151.1
  • unusual splice
NP_001260152.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6719394..6723359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273221.1 → NP_001260150.1  homer, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260150.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ7, O96607
    Conserved Domains (2) summary
    cd01206
    Location:3 → 111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:262 → 373
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_164706.2 → NP_723207.1  homer, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ7, Q9VM94
    Related
    FBpp0078937
    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:265 → 376
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_001273222.1 → NP_001260151.1  homer, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260151.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ7, M9PEX1
    Conserved Domains (2) summary
    cd01206
    Location:9 → 117
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:268 → 379
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. NM_058048.4 → NP_477396.1  homer, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477396.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ7, O96607
    Related
    FBpp0078936
    Conserved Domains (2) summary
    cd01206
    Location:3 → 111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:262 → 373
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. NM_001042876.2 → NP_001036341.2  homer, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036341.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8S7
    Conserved Domains (1) summary
    cd01206
    Location:3 → 111
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  6. NM_001273223.1 → NP_001260152.1  homer, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ7, M9PB54
    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    cl23720
    Location:265 → 376
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB54 M9PB54
M9PEX1 M9PEX1
O96607 O96607
Q0E8S7 Q0E8S7
Q9VM94 Q9VM94

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