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LUBEL - Linear Ubiquitin E3 ligase

Enables linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including heat acclimation; positive regulation of peptidoglycan recognition protein signaling pathway; and protein linear polyubiquitination. Predicted to be part of LUBAC complex. Is expressed in dorsal pharyngeal muscle cell; larval somatic muscle cell; and somatic muscle primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa