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nop5 nop5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33966, updated on 4-Jan-2025

Summary

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Official Symbol
nop5provided by FlyBase
Official Full Name
nop5provided by FlyBase
Primary source
FLYBASE:FBgn0026196
Locus tag
Dmel_CG10206
See related
AllianceGenome:FB:FBgn0026196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2/30; CG10206; Dmel\CG10206; Dnop5; DNOP5; Nop5; NOP5
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus. Is expressed in several structures, including embryonic/larval midgut primordium; gonad; gut section; head epidermis primordium; and imaginal disc. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See nop5 in Genome Data Viewer
Location:
27C4-27C4; 2-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6916753..6918743, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6916753..6918743, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rat1 5'-3' exoribonuclease Neighboring gene ncRNA Neighboring gene Wee1 kinase Neighboring gene uncharacterized protein Neighboring gene x16 splicing factor Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila. Murata T, et al. Biosci Biotechnol Biochem, 2008 Sep. PMID 18776683
  2. Restricted expression and subnuclear localization of the Drosophila gene Dnop5, a member of the Nop/Sik family of the conserved rRNA processing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640717
  3. Localized expression of the Drosophila gene Dxl6, a novel member of the serine/arginine rich (SR) family of splicing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640718
  4. Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts. Hovhanyan A, et al. Mol Cell Biol, 2014 May. PMID 24615015, Free PMC Article
  5. The EGF/Ras pathway controls growth in Drosophila via ribosomal RNA synthesis. Sriskanthadevan-Pirahas S, et al. Dev Biol, 2018 Jul 1. PMID 29660312

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box C/D methylation guide snoRNP complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nop5
Names
CG10206-PA
nop5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6916753..6918743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058064.5 → NP_477412.1  nop5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ANY9, Q9U5W4, Q9VM69
    Related
    FBpp0078997
    Conserved Domains (3) summary
    smart00931
    Location:163 → 214
    NOSIC; NOSIC (NUC001) domain
    pfam01798
    Location:169 → 397
    Nop; snoRNA binding domain, fibrillarin
    pfam08156
    Location:2 → 52
    NOP5NT; NOP5NT (NUC127) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U5W4 Q9U5W4
Q9VM69 Q9VM69

Gene LinkOut

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