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x16 x16 splicing factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33967, updated on 9-Dec-2024

Summary

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Official Symbol
x16provided by FlyBase
Official Full Name
x16 splicing factorprovided by FlyBase
Primary source
FLYBASE:FBgn0028554
Locus tag
Dmel_CG10203
See related
AllianceGenome:FB:FBgn0028554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2/30; 9G8; anon-WO0118547.78; CG10203; d9G8; Dmel\CG10203; dx16; Dx16; dxl6; Dxl6; l(2)k00230; RBP1-like; TN166; X16; X16/9G8; xl6; Xl6; XL6
Summary
Enables mRNA binding activity. Involved in RNA splicing and regulation of RNA metabolic process. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and imaginal disc. Orthologous to several human genes including SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See x16 in Genome Data Viewer
Location:
27C4-27C4; 2-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6914301..6920210, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6914301..6920210, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit F Neighboring gene Rat1 5'-3' exoribonuclease Neighboring gene ncRNA Neighboring gene Wee1 kinase Neighboring gene uncharacterized protein Neighboring gene nop5 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of RNA binding sequences of Drosophila SR protein DX16. Yuan L, et al. Mol Cell Biochem, 2007 Aug. PMID 17345156
  2. The regulation of carnitine palmitoyltransferase 1 (CPT1) mRNA splicing by nutrient availability in Drosophila fat tissue. Truong HG, et al. Biochem Biophys Rep, 2024 Jul. PMID 38384389, Free PMC Article
  3. Restricted expression and subnuclear localization of the Drosophila gene Dnop5, a member of the Nop/Sik family of the conserved rRNA processing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640717
  4. DX16 is a novel SR protein phosphorylated by DOA. Wan Y, et al. Mol Cell Biochem, 2008 Jan. PMID 17828581
  5. Localized expression of the Drosophila gene Dxl6, a novel member of the serine/arginine rich (SR) family of splicing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640718

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
x16 splicing factor
Names
CG10203-PA
CG10203-PB
x16-PA
x16-PB
xl6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6914301..6920210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273239.2 → NP_001260168.1  x16 splicing factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260168.1

    Status: REVIEWED

    Conserved Domains (3) summary
    smart00343
    Location:116 → 132
    ZnF_C2HC; zinc finger
    COG0724
    Location:1 → 82
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:9 → 81
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

  2. NM_164718.2 → NP_723226.1  x16 splicing factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723226.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PC85, Q9V3V0
    Related
    FBpp0078996
    Conserved Domains (2) summary
    COG0724
    Location:1 → 82
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:9 → 81
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PC85 M9PC85
Q9V3V0 Q9V3V0

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