snRNP-U1-70K small ribonucleoprotein particle U1 subunit 70K [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: snRNP-U1-70Kprovided by FlyBase
Official Full Name: small ribonucleoprotein particle U1 subunit 70Kprovided by FlyBase
Primary source: FLYBASE:FBgn0016978
Locus tag: Dmel_CG8749
See related: AllianceGenome:FB:FBgn0016978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 70K; CG8749; Dm70K; Dmel\CG8749; dU1-70K; l(2)02107; snRNP; snRNP 70K; SnRNP-U1-70K; snRNP27D; snRNP70K; snRNPU1-70K; U1; U1 70k; U1 70K; U1 70K snRNP; U1 snRNP; U1-70k; U1-70K; U170K; U1snRNP-70K
Summary: Enables mRNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome; oogenesis; and spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including central brain primordium; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6968711..6971737, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6968711..6971737, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

U1 snRNP regulates cancer gene expression, cellmigration and invasion.
Title: U1 snRNP regulates cancer cell migration and invasion in vitro.
SEX-LETHAL associates with U1 snRNP components in male exon skipping
Title: Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping.
not essential for viability, nevertheless contribute to an essential U1 snRNP function.
Title: The Drosophila U1-70K protein is required for viability, but its arginine-rich domain is dispensable.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U1 snRNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IPI Inferred from Physical Interaction more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of U2-type prespliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IC Inferred by Curator more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info

Names: CG8749-PA; CG8749-PC; U1 snRNP-specific 70K protein; small nuclear ribonucleoprotein 70K; snRNP-U1-70K-PA; snRNP-U1-70K-PC

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The following sections contain reference sequences that belong to a specific genome build. Explain