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Mnn1 - Menin 1

Predicted to enable Y-form DNA binding activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and regulation of JNK cascade. Located in nucleus. Part of MLL1/2 complex. Is expressed in several structures, including anterior spiracle primordium; anterior-posterior subdivision of organism; and ectoderm. Used to study multiple endocrine neoplasia type 1. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

How was this calculated?
  • arthropods

324 genes for: arthropods (Arthropoda)