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Pvf2 PDGF- and VEGF-related factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33994, updated on 4-Jan-2025

Summary

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Official Symbol
Pvf2provided by FlyBase
Official Full Name
PDGF- and VEGF-related factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0031888
Locus tag
Dmel_CG13780
See related
AllianceGenome:FB:FBgn0031888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13780; Dmel\CG13780; DmVEGF-2; PV2; Pvf; PVF; pvf2; PVF2; PVFs; VEGF; VEGF-2; Vegf27Cb; VEGF27Cb
Summary
Enables chemoattractant activity. Involved in several processes, including hemocyte migration; hemocyte proliferation; and positive regulation of cell size. Acts upstream of with a positive effect on neuron remodeling. Is active in extracellular space. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; cardiogenic mesoderm; gut section; and intestinal stem cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pvf2 in Genome Data Viewer
Location:
27E1-27E1; 2-25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7069536..7084635, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7069536..7084635, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Menin 1 Neighboring gene Male specific transcript 27D Neighboring gene UDP-glycosyltransferase family 307 member A1 Neighboring gene Suppressor of exocyst mutations 1 Neighboring gene Nuf2 Neighboring gene long non-coding RNA:CR44611 Neighboring gene long non-coding RNA:CR46196 Neighboring gene PDGF- and VEGF-related factor 3 Neighboring gene long non-coding RNA:CR44612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila model for microbiome research. Douglas AE. Lab Anim (NY), 2018 Jun. PMID 29795158, Free PMC Article
  2. Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2. Bakopoulos D, et al. FEBS J, 2022 Jul. PMID 35066977
  3. Walking the walk: migration and other common themes in blood and vascular development. Traver D, et al. Cell, 2002 Mar 22. PMID 11955426
  4. A deregulated intestinal cell cycle program disrupts tissue homeostasis without affecting longevity in Drosophila. Petkau K, et al. J Biol Chem, 2014 Oct 10. PMID 25170078, Free PMC Article
  5. The Drosophila VEGF receptor homolog is expressed in hemocytes. Heino TI, et al. Mech Dev, 2001 Nov. PMID 11677054

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
    Title: Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
  2. Data show that Pvf2 and Pvf3 are not required for the directed migration of hemocytes, but act locally in epithelial cells to coordinate trans-epithelial migration of hemocytes.
    Title: The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration.
  3. An age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations.
    Title: Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chemoattractant activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hemocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hemocyte migration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hemocyte migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of humoral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PDGF- and VEGF-related factor 2
Names
CG13780-PA
PDGF- and VEGF-receptor related factor 2
Pvf2-PA
VEGF-related factor 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7069536..7084635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078775.3 → NP_523499.2  PDGF- and VEGF-related factor 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523499.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PU5, Q9VM43
    Related
    FBpp0079051
    Conserved Domains (1) summary
    cl00116
    Location:204 → 280
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM43 Q9VM43

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