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MICU1 Mitochondrial calcium uptake 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33999, updated on 4-Jan-2025

Summary

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Official Symbol
MICU1provided by FlyBase
Official Full Name
Mitochondrial calcium uptake 1provided by FlyBase
Primary source
FLYBASE:FBgn0031893
Locus tag
Dmel_CG4495
See related
AllianceGenome:FB:FBgn0031893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4495; Dmel\CG4495; micu1
Summary
Predicted to enable calcium ion binding activity. Involved in anesthesia-resistant memory; calcium import into the mitochondrion; and medium-term memory. Predicted to be part of uniplex complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and head mesoderm. Used to study myopathy with extrapyramidal signs. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See MICU1 in Genome Data Viewer
Location:
27E4-27E4; 2-25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7182234..7185529)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7182234..7185529)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46210 Neighboring gene long non-coding RNA:CR44613 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of mitochondrial calcium uptake 1 in Drosophila neurons. M'Angale PG, et al. Genet Mol Res, 2017 Feb 8. PMID 28198506
  2. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila. Drago I, et al. Cell Rep, 2016 Sep 6. PMID 27568554, Free PMC Article
  3. Parallel adaptive feedback enhances reliability of the Ca2+ signaling system. Abell E, et al. Proc Natl Acad Sci U S A, 2011 Aug 30. PMID 21844332, Free PMC Article
  4. Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo. Tufi R, et al. Cell Rep, 2019 Apr 30. PMID 31042479, Free PMC Article
  5. Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression. Pareek G, et al. PLoS Genet, 2020 Oct. PMID 33075064, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MICU1 mutants are developmentally lethal, consistent with unregulated Ca2+ uptake.
    Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium import into the mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium import into the mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of uniplex complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of uniplex complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial calcium uptake 1
Names
CG4495-PA
CG4495-PB
MICU1-PA
MICU1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7182234..7185529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103640.2 → NP_001097110.1  mitochondrial calcium uptake 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEI2, Q9VM38
    Conserved Domains (2) summary
    pfam13833
    Location:438 → 491
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:252 → 293
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_135256.3 → NP_609100.1  mitochondrial calcium uptake 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609100.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEI2
    Related
    FBpp0079033
    Conserved Domains (2) summary
    pfam13833
    Location:437 → 490
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:251 → 292
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VEI2.1 A2VEI2

Gene LinkOut

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