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CG4502 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34002, updated on 4-Jan-2025

Summary

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Official Symbol
CG4502provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031896
Locus tag
Dmel_CG4502
See related
AllianceGenome:FB:FBgn0031896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.403; Dmel\CG4502
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Is expressed in several structures, including ganglia; germline cell; gonad; and larval nervous system. Orthologous to human UBE2QL1 (ubiquitin conjugating enzyme E2 QL1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG4502 in Genome Data Viewer
Location:
27E4-27E4; 2-25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7194908..7204264, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7194908..7204264, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Mitochondrial calcium uptake 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44989 Neighboring gene mitochondrial translation elongation factor G 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila. Landayan D, et al. Elife, 2021 May 21. PMID 34018925, Free PMC Article
  2. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
  3. Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza M, et al. PLoS Genet, 2015 Mar. PMID 25826266, Free PMC Article
  4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
  5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4502-PA
CG4502-PB
NP_609103.1
NP_723260.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7194908..7204264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135259.3 → NP_609103.1  uncharacterized protein Dmel_CG4502, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM35
    Related
    FBpp0079045
    Conserved Domains (1) summary
    cd00195
    Location:140 → 258
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_164741.2 → NP_723260.1  uncharacterized protein Dmel_CG4502, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723260.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM35
    Related
    FBpp0079044
    Conserved Domains (1) summary
    cd00195
    Location:140 → 258
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM35.1 Q9VM35

Gene LinkOut

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