mEFG1 mitochondrial translation elongation factor G 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mEFG1provided by FlyBase
Official Full Name: mitochondrial translation elongation factor G 1provided by FlyBase
Primary source: FLYBASE:FBgn0263133
Locus tag: Dmel_CG4567
See related: AllianceGenome:FB:FBgn0263133
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: B; CG4567; dEF-G1; Dmel\CG4567; G; GFM1; ico; l(2)27Cb; l(2)27Ea
Summary: Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7220369..7223081, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7220369..7223081, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling.
Title: The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translational elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG4567-PA; complementation group B; complementation group G; iconoclast; lethal (2) 27Cb; lethal (2) 27Ea; mEFG1-PA

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The following sections contain reference sequences that belong to a specific genome build. Explain