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Ndae1 Na[+]-driven anion exchanger 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34005, updated on 4-Jan-2025

Summary

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Official Symbol
Ndae1provided by FlyBase
Official Full Name
Na[+]-driven anion exchanger 1provided by FlyBase
Primary source
FLYBASE:FBgn0259111
Locus tag
Dmel_CG42253
See related
AllianceGenome:FB:FBgn0259111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153385_at; anon-WO0257455.13; CG31906; CG42253; CG4675; Dmel\CG42253; l(2)k10316; Ndae-1; ndae1; NDAE1
Old locus tag
Dmel_CG31906; Dmel_CG4675
Summary
Enables sodium:bicarbonate symporter activity. Involved in bicarbonate transport; monoatomic ion transmembrane transport; and regulation of cellular pH. Located in plasma membrane. Is expressed in several structures, including adult aorta; anlage in statu nascendi; anterior-posterior subdivision of organism; epithelium; and ganglia. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10) and SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ndae1 in Genome Data Viewer
Location:
27E5-27E7; 2-25 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7223328..7249343, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7223328..7249343, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44989 Neighboring gene mitochondrial translation elongation factor G 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Wnt oncogene analog 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. Romero MF, et al. J Biol Chem, 2000 Aug 11. PMID 10827195
  2. Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster. Sciortino CM, et al. Am J Physiol Cell Physiol, 2001 Aug. PMID 11443044
  3. Inorganic and organic anion transport by insect renal epithelia. O'Donnell MJ, et al. Biochim Biophys Acta, 2003 Dec 30. PMID 14729156
  4. Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons. Morioka E, et al. Cell Rep, 2022 May 10. PMID 35545046
  5. Ndae1 expression and regulation in Drosophila embryos. Tevy MF, et al. PLoS One, 2014. PMID 24676142, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:bicarbonate symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicarbonate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Na[+]-driven anion exchanger 1
Names
CG42253-PA
CG42253-PB
CG42253-PC
CG42253-PD
CG42253-PE
CG42253-PF
CG42253-PG
CG42253-PH
CG42253-PI
CG42253-PJ
Ndae1-PA
Ndae1-PB
Ndae1-PC
Ndae1-PD
Ndae1-PE
Ndae1-PF
Ndae1-PG
Ndae1-PH
Ndae1-PI
Ndae1-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7223328..7249343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273248.1 → NP_001260177.1  Na[+]-driven anion exchanger 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB59, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:127 → 1003
    ae; anion exchange protein
    pfam00955
    Location:463 → 955
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:154 → 422
    Band_3_cyto; Band 3 cytoplasmic domain

  2. NM_001273254.1 → NP_001260183.1  Na[+]-driven anion exchanger 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260183.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC95, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:71 → 1003
    ae; anion exchange protein
    pfam00955
    Location:463 → 955
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:98 → 422
    Band_3_cyto; Band 3 cytoplasmic domain

  3. NM_164743.3 → NP_723263.2  Na[+]-driven anion exchanger 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723263.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPI3, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:140 → 1016
    ae; anion exchange protein
    pfam00955
    Location:476 → 968
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:167 → 435
    Band_3_cyto; Band 3 cytoplasmic domain

  4. NM_001273249.1 → NP_001260178.1  Na[+]-driven anion exchanger 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC92, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:127 → 1003
    ae; anion exchange protein
    pfam00955
    Location:463 → 955
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:154 → 422
    Band_3_cyto; Band 3 cytoplasmic domain

  5. NM_001273252.1 → NP_001260181.1  Na[+]-driven anion exchanger 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260181.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF01, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:71 → 970
    ae; anion exchange protein
    pfam00955
    Location:430 → 922
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:98 → 389
    Band_3_cyto; Band 3 cytoplasmic domain

  6. NM_001273250.1 → NP_001260179.1  Na[+]-driven anion exchanger 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCT2, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:87 → 944
    ae; anion exchange protein
    pfam00955
    Location:404 → 896
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:114 → 363
    Band_3_cyto; Band 3 cytoplasmic domain

  7. NM_078777.3 → NP_523501.1  Na[+]-driven anion exchanger 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQK6, Q9GZG7, Q9VM32
    Related
    FBpp0288812
    Conserved Domains (3) summary
    TIGR00834
    Location:71 → 947
    ae; anion exchange protein
    pfam00955
    Location:407 → 899
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:98 → 366
    Band_3_cyto; Band 3 cytoplasmic domain

  8. NM_001273251.1 → NP_001260180.1  Na[+]-driven anion exchanger 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCF0, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:71 → 984
    ae; anion exchange protein
    pfam00955
    Location:444 → 936
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:98 → 403
    Band_3_cyto; Band 3 cytoplasmic domain

  9. NM_164744.2 → NP_723264.1  Na[+]-driven anion exchanger 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723264.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQK6, Q9VM31
    Related
    FBpp0288813
    Conserved Domains (3) summary
    TIGR00834
    Location:140 → 1016
    ae; anion exchange protein
    pfam00955
    Location:476 → 968
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:167 → 435
    Band_3_cyto; Band 3 cytoplasmic domain

  10. NM_001273253.1 → NP_001260182.1  Na[+]-driven anion exchanger 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260182.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB60, Q8MQK6
    Conserved Domains (3) summary
    TIGR00834
    Location:140 → 1043
    ae; anion exchange protein
    pfam00955
    Location:503 → 995
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:167 → 462
    Band_3_cyto; Band 3 cytoplasmic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB59 M9PB59
M9PB60 M9PB60
M9PC92 M9PC92
M9PC95 M9PC95
M9PCF0 M9PCF0
M9PCT2 M9PCT2
M9PF01 M9PF01
Q8IPI3 Q8IPI3
Q8MQK6 Q8MQK6
Q9VM31 Q9VM31
Q9VM32 Q9VM32

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