U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ninaC neither inactivation nor afterpotential C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34012, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ninaCprovided by FlyBase
Official Full Name
neither inactivation nor afterpotential Cprovided by FlyBase
Primary source
FLYBASE:FBgn0002938
Locus tag
Dmel_CG5125
See related
AllianceGenome:FB:FBgn0002938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2.2; CG 5125; CG5125; CG54125; CT16120; CT42491; Dm NinaC; Dmel\CG5125; DRONINAC; Myo1B; Nina C; NINA C; ninac; NinaC; NINAC
Summary
Enables calmodulin binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Involved in several processes, including dsRNA transport; photoreceptor cell maintenance; and phototransduction. Located in cytoplasm; nucleus; and rhabdomere membrane. Part of inaD signaling complex. Is expressed in embryonic head epidermis; embryonic head sensory system; eye; head; and rhabdomere. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 30. Orthologous to several human genes including MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ninaC in Genome Data Viewer
Location:
27F3-27F3; 2-26 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7377702..7384344)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7377702..7384344)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Wnt oncogene analog 6 Neighboring gene Wnt oncogene analog 10 Neighboring gene antisense RNA:CR44063 Neighboring gene uncharacterized protein Neighboring gene gudu

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Calmodulin regulation of calcium stores in phototransduction of Drosophila. Arnon A, et al. Science, 1997 Feb 21. PMID 9027311
  2. Identification of myosin III as a protein kinase. Ng KP, et al. Biochemistry, 1996 Jul 23. PMID 8755717
  3. One motor, many tails: an expanding repertoire of force-generating enzymes. Vale RD, et al. Cell, 1990 Mar 23. PMID 2138513
  4. Genome-wide sequencing and an open reading frame analysis of dichlorodiphenyltrichloroethane (DDT) susceptible (91-C) and resistant (91-R) Drosophila melanogaster laboratory populations. Steele LD, et al. PLoS One, 2014. PMID 24915415, Free PMC Article
  5. Differential effects of ninaC proteins (p132 and p174) on light-activated currents and pupil mechanism in Drosophila photoreceptors. Hofstee CA, et al. Vis Neurosci, 1996 Sep-Oct. PMID 8903032

See all (185) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rapid calcium (Ca2+)/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction.
    Title: Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.
  2. Termination of phototransduction requires a complex with NINAC and retinophilin, a complex which provides stability to protein kinase C and INAD (inactivation no afterpotential D).
    Title: Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction.
  3. Data suggest that the photoreceptor-specific myosin III NINAC is involved in G(q)alpha transport in Drosophila photoreceptors.
    Title: Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC.
  4. The light-dependent translocation of Arr2 into Drosophila rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III.
    Title: Light-dependent translocation of visual arrestin regulated by the NINAC myosin III.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables protein tyrosine kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, visible light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to rhabdomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin filament length IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of inaD signaling complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of inaD signaling complex TAS
Traceable Author Statement
more info
 PubMed 
part_of myosin III complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neither inactivation nor afterpotential C
Names
CG5125-PA
CG5125-PB
CG5125-PC
CG5125-PD
NINAC myosin III
droninac
either inactivation nor afterpotential C
myosin III
myosin-III
neither inactivation Nor afterpotential C
neither inactivation nor after potential C
neither inactivation nor afterpotential-C
ninaC-PA
ninaC-PB
ninaC-PC
ninaC-PD
NP_001260189.1
NP_001260190.1
NP_523503.2
NP_723271.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7377702..7384344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078779.3 → NP_523503.2  neither inactivation nor afterpotential C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523503.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10676, P10677, Q8MRP1, Q9VM23, Q9VM24
    Related
    FBpp0079064
    Conserved Domains (4) summary
    smart00220
    Location:16 → 282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00242
    Location:327 → 1034
    MYSc; Myosin. Large ATPases
    cd06608
    Location:9 → 282
    STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
    cd14882
    Location:346 → 1022
    MYSc_Myo21; class XXI myosin, motor domain

  2. NM_001273260.1 → NP_001260189.1  neither inactivation nor afterpotential C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU0
    Conserved Domains (4) summary
    smart00220
    Location:16 → 282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00242
    Location:327 → 1034
    MYSc; Myosin. Large ATPases
    cd06608
    Location:9 → 282
    STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
    cd14882
    Location:346 → 1022
    MYSc_Myo21; class XXI myosin, motor domain

  3. NM_164747.1 → NP_723271.1  neither inactivation nor afterpotential C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU0
    Related
    FBpp0079065, FBtr0079437
    Conserved Domains (4) summary
    smart00220
    Location:16 → 282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00242
    Location:327 → 1034
    MYSc; Myosin. Large ATPases
    cd06608
    Location:9 → 282
    STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
    cd14882
    Location:346 → 1022
    MYSc_Myo21; class XXI myosin, motor domain

  4. NM_001273261.1 → NP_001260190.1  neither inactivation nor afterpotential C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU0
    Conserved Domains (4) summary
    smart00220
    Location:16 → 282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00242
    Location:327 → 1034
    MYSc; Myosin. Large ATPases
    cd06608
    Location:9 → 282
    STKc_myosinIII_N_like; N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases
    cd14882
    Location:346 → 1022
    MYSc_Myo21; class XXI myosin, motor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCU0 M9PCU0
P10676.2 P10676

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools