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CG5973 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34023, updated on 4-Jan-2025

Summary

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Official Symbol
CG5973provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031914
Locus tag
Dmel_CG5973
See related
AllianceGenome:FB:FBgn0031914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5973
Summary
Predicted to enable phosphatidylinositol bisphosphate binding activity. Is expressed in adult head; amnioserosa; embryonic/larval midgut; and yolk nucleus. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5973 in Genome Data Viewer
Location:
27F4-28A1; 2-26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7437492..7445882)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7437492..7445882)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midline uncoordinated Neighboring gene uncharacterized protein Neighboring gene scavenger receptor acting in neural tissue and majority of rhodopsin is absent Neighboring gene Gustatory receptor 28a Neighboring gene Gustatory receptor 28b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. Wang T, et al. J Cell Biol, 2007 Apr 23. PMID 17452532, Free PMC Article
  2. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
  3. Identification of receptor-tyrosine-kinase-signaling target genes reveals receptor-specific activities and pathway branchpoints during Drosophila development. Leatherbarrow JR, et al. Genetics, 2009 Apr. PMID 19189950, Free PMC Article
  4. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343
  5. Drosophila ribosomal proteins are associated with linker histone H1 and suppress gene transcription. Ni JQ, et al. Genes Dev, 2006 Jul 15. PMID 16816001, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5973-PA
CG5973-PB
CG5973-PC
CG5973-PD
CG5973-PE
CG5973-PF
CG5973-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7437492..7445882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273268.2 → NP_001260197.1  uncharacterized protein Dmel_CG5973, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260197.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  2. NM_164750.2 → NP_723275.1  uncharacterized protein Dmel_CG5973, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723275.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Related
    FBpp0079074
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  3. NM_001169430.3 → NP_001162901.1  uncharacterized protein Dmel_CG5973, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  4. NM_001273269.1 → NP_001260198.1  uncharacterized protein Dmel_CG5973, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260198.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  5. NM_164751.2 → NP_723276.1  uncharacterized protein Dmel_CG5973, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723276.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Related
    FBpp0079075
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  6. NM_135276.3 → NP_609120.1  uncharacterized protein Dmel_CG5973, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609120.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Related
    FBpp0079076
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  7. NM_001298781.1 → NP_001285710.1  uncharacterized protein Dmel_CG5973, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285710.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM11
    Conserved Domains (2) summary
    smart01100
    Location:51 → 96
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:116 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM11 Q9VM11

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