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RapGAP1 Rap GTPase activating protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34032, updated on 4-Jan-2025

Summary

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Official Symbol
RapGAP1provided by FlyBase
Official Full Name
Rap GTPase activating protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0264895
Locus tag
Dmel_CG44086
See related
AllianceGenome:FB:FBgn0264895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13789; CG13790; CG13791; CG33529; CG34374; CG44086; CG6682; Dmel\CG44086; FBpp0111515; Q9VM02_DROME; rapgap; RapGAP; rapgap1; rapGAP1; Rapgap1; RapGap1
Old locus tag
CG13790; CG33529; Dmel_CG13790; Dmel_CG13791; Dmel_CG33529; Dmel_CG34374
Summary
Enables GTPase activator activity. Involved in negative regulation of small GTPase mediated signal transduction. Located in germ plasm. Is expressed in several structures, including efferent neurons; epithelium; germline cell; gut section; and head epidermis primordium. Orthologous to several human genes including RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See RapGAP1 in Genome Data Viewer
Location:
28A4-28B2; 2-27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7497805..7578980, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7497805..7578980, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zizimin Neighboring gene Odorant-binding protein 28a Neighboring gene long non-coding RNA:CR44082 Neighboring gene long non-coding RNA:CR46063 Neighboring gene long non-coding RNA:CR46535 Neighboring gene Serpin 28B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The molecular signature of BCR::ABL(P210) and BCR::ABL(T315I) in a Drosophila melanogaster chronic myeloid leukemia model. Baassiri A, et al. iScience, 2024 Apr 19. PMID 38585663, Free PMC Article
  2. Genomic mapping and expression patterns of C380, OK6 and D42 enhancer trap lines in the larval nervous system of Drosophila. Sanyal S. Gene Expr Patterns, 2009 Jun. PMID 19602393
  3. The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Marqués G, et al. Neuron, 2002 Feb 14. PMID 11856528
  4. Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Kopein D, et al. Mol Biol Cell, 2009 Sep. PMID 19570914, Free PMC Article
  5. Rap1 GTPase promotes coordinated collective cell migration in vivo. Sawant K, et al. Mol Biol Cell, 2018 Nov 1. PMID 30156466, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c7550514-7548136 mobile_element_type = transposon:Burdock{}320

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in germ plasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rap GTPase activating protein 1
Names
CG44086-PD
CG44086-PE
CG44086-PF
CG44086-PH
CG44086-PI
RapGAP1-PD
RapGAP1-PE
RapGAP1-PF
RapGAP1-PH
RapGAP1-PI
Rapgap1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7497805..7578980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103644.3 → NP_001097114.2  Rap GTPase activating protein 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097114.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYW8, O44090
    Conserved Domains (2) summary
    pfam02145
    Location:460 → 639
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:147 → 168
    GoLoco; GoLoco motif

  2. NM_144299.3 → NP_652556.2  Rap GTPase activating protein 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652556.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44090, Q9VM00
    Conserved Domains (2) summary
    pfam02145
    Location:434 → 613
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:121 → 142
    GoLoco; GoLoco motif

  3. NM_001273279.1 → NP_001260208.1  Rap GTPase activating protein 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44090, Q9VM00
    Conserved Domains (2) summary
    pfam02145
    Location:434 → 613
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:121 → 142
    GoLoco; GoLoco motif

  4. NM_001014479.2 → NP_001014479.1  Rap GTPase activating protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014479.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44090, Q59DZ5
    Conserved Domains (2) summary
    pfam02145
    Location:377 → 556
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:64 → 85
    GoLoco; GoLoco motif

  5. NM_001014478.2 → NP_001014478.1  Rap GTPase activating protein 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014478.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44090, Q9VM02
    Conserved Domains (1) summary
    pfam02145
    Location:351 → 530
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYW8 A8DYW8
O44090 O44090
Q59DZ5 Q59DZ5
Q95SF4 Q95SF4
Q9VM00 Q9VM00
Q9VM02 Q9VM02

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