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Tep2 Thioester-containing protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34044, updated on 4-Jan-2025

Summary

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Official Symbol
Tep2provided by FlyBase
Official Full Name
Thioester-containing protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0041182
Locus tag
Dmel_CG7052
See related
AllianceGenome:FB:FBgn0041182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
145970_at; 145971_at; CG18589; CG7052; Dmel\CG7052; dTEPII; T13; Tep 2; Tep II; TEP II; tep2; TEP2; TEP2mel; tepII; TepII
Summary
Predicted to enable endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium and innate immune response. Located in extracellular space. Is expressed in several structures, including anterior-posterior subdivision of organism; crop; embryonic/larval corpus allatum; embryonic/larval fat body; and embryonic/larval hemocyte. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tep2 in Genome Data Viewer
Location:
28C1-28C1; 2-28 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7693727..7701601, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7693727..7701601, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Myosin 28B1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44990 Neighboring gene Thioester-containing protein 3 Neighboring gene transfer RNA:Tyrosine-GTA 1-9 Neighboring gene Neurotransmitter transporter-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus. Shokal U, et al. Virulence, 2017 Nov 17. PMID 28498729, Free PMC Article
  2. Thioester-Containing Proteins 2 and 4 Affect the Metabolic Activity and Inflammation Response in Drosophila. Shokal U, et al. Infect Immun, 2018 May. PMID 29463615, Free PMC Article
  3. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
  4. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
  5. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Eleftherianos I, et al. Insects, 2020 Jan 28. PMID 32013030, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of Tep2 or Tep6 affects phagocytosis and melanization in flies infected with Photorhabdus.
    Title: The distinct function of Tep2 and Tep6 in the immune defense of Drosophila melanogaster against the pathogen Photorhabdus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thioester-containing protein 2
Names
CG7052-PA
CG7052-PB
CG7052-PD
CG7052-PF
CG7052-PG
TEP
Tep2-PA
Tep2-PB
Tep2-PD
Tep2-PF
Tep2-PG
thioester containing protein II
thiolester containing protein II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7693727..7701601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164762.2 → NP_723299.2  Thioester-containing protein 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723299.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZWQ3, Q9VLZ0
    Conserved Domains (6) summary
    cd02897
    Location:898 → 1187
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:681 → 771
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:115 → 209
    A2M_N; MG2 domain
    pfam07677
    Location:1297 → 1387
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:950 → 1188
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:445 → 576
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  2. NM_164763.2 → NP_723300.2  Thioester-containing protein 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723300.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZWQ4, Q8IPH5
    Conserved Domains (6) summary
    cd02897
    Location:889 → 1178
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:670 → 762
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:115 → 209
    A2M_N; MG2 domain
    pfam07677
    Location:1288 → 1378
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:941 → 1179
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:445 → 576
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  3. NM_078782.3 → NP_523506.1  Thioester-containing protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZWQ0, A0ZWQ1, Q9NFV7, Q9VLY8
    Related
    FBpp0079133
    Conserved Domains (6) summary
    cd02897
    Location:909 → 1198
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:694 → 782
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:115 → 209
    A2M_N; MG2 domain
    pfam07677
    Location:1308 → 1398
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:961 → 1199
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:445 → 576
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  4. NM_164761.2 → NP_723298.1  Thioester-containing protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723298.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZWQ2, Q9VLY9
    Related
    FBpp0079134
    Conserved Domains (6) summary
    cd02897
    Location:888 → 1177
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:671 → 761
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:115 → 209
    A2M_N; MG2 domain
    pfam07677
    Location:1287 → 1377
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:940 → 1178
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:445 → 576
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  5. NM_164764.2 → NP_723301.1  Thioester-containing protein 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZWQ5, Q8IPH4
    Related
    FBpp0079136
    Conserved Domains (6) summary
    cd02897
    Location:897 → 1186
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:679 → 770
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:115 → 209
    A2M_N; MG2 domain
    pfam07677
    Location:1296 → 1386
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:949 → 1187
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:445 → 576
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IPH4 Q8IPH4
Q8IPH5 Q8IPH5
Q8MT94 Q8MT94
Q9NFV7 Q9NFV7
Q9VLY9 Q9VLY9
Q9VLZ0 Q9VLZ0

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