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SATL1 spermidine/spermine N1-acetyl transferase like 1 [ Homo sapiens (human) ]

Gene ID: 340562, updated on 27-Nov-2024

Summary

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Official Symbol
SATL1provided by HGNC
Official Full Name
spermidine/spermine N1-acetyl transferase like 1provided by HGNC
Primary source
HGNC:HGNC:27992
See related
Ensembl:ENSG00000184788 MIM:301129; AllianceGenome:HGNC:27992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable diamine N-acetyltransferase activity and spermidine binding activity. Predicted to be involved in spermidine acetylation. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 5.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SATL1 in Genome Data Viewer
Location:
Xq21.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (85092284..85243779, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (83521243..83672628, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84347290..84498785, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 16, pseudogene Neighboring gene SET pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene) Neighboring gene apolipoprotein O like Neighboring gene uncharacterized LOC101928128 Neighboring gene zinc finger protein 711 Neighboring gene POF1B actin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H. Imai H, et al. Oncol Rep, 2014 Mar. PMID 24378760, Free PMC Article
  2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  3. Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. Schaefer KN, et al. Mol Biol Cell, 2020 May 1. PMID 32129710, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables diamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in spermidine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spermidine/spermine N(1)-acetyltransferase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016590.2 RefSeqGene

    Range
    139812..156494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012980.2 → NP_001012998.2  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC043215, Z99571
    Consensus CDS
    CCDS35343.2
    UniProtKB/Swiss-Prot
    Q86VE3
    Related
    ENSP00000425421.1, ENST00000509231.1
    Conserved Domains (1) summary
    pfam03157
    Location:81 → 508
    Glutenin_hmw; High molecular weight glutenin subunit

  2. NM_001367857.2 → NP_001354786.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC003001, Z83820, Z99571
    Consensus CDS
    CCDS94638.1
    UniProtKB/Swiss-Prot
    A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3
    Related
    ENSP00000494345.1, ENST00000644105.2
    Conserved Domains (2) summary
    pfam00583
    Location:543 → 668
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam03157
    Location:109 → 541
    Glutenin_hmw; High molecular weight glutenin subunit

  3. NM_001367858.2 → NP_001354787.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC003001, Z83820, Z99571
    Consensus CDS
    CCDS94637.1
    UniProtKB/TrEMBL
    A0A2R8YFQ0
    Related
    ENSP00000495329.1, ENST00000646235.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    85092284..85243779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442081.1 → XP_047298037.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    83521243..83672628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326989.1 → XP_054182964.1  spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8Y5C1, A0AVK7, E9PB72, Q5H8V9, Q86VE3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001163541.1: Suppressed sequence

    Description
    NM_001163541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VE3.4 GenPept UniProtKB/Swiss-Prot:Q86VE3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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