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CG7149 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34063, updated on 9-Dec-2024

Summary

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Official Symbol
CG7149provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031948
Locus tag
Dmel_CG7149
See related
AllianceGenome:FB:FBgn0031948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cpt; dCCS3; Dmel\CG7149
Summary
Predicted to enable ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval salivary gland; fat body; and larval central nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to human SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG7149 in Genome Data Viewer
Location:
28C3-28C4; 2-28 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7786160..7790557, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7786160..7790557, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bromodomain containing 7/9 Neighboring gene Lysine ketoglutarate reductase/saccharopine dehydrogenase Neighboring gene long non-coding RNA:CR44825 Neighboring gene Homocysteine-induced endoplasmic reticulum protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
  2. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. Midorikawa R, et al. J Neurosci, 2010 Aug 11. PMID 20702701, Free PMC Article
  3. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
  4. Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function. Martínez BA, et al. PLoS Genet, 2020 Nov. PMID 33227003, Free PMC Article
  5. A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research. Kockel L, et al. G3 (Bethesda), 2016 Oct 13. PMID 27527793, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7149-PA
CG7149-PB
CG7149-PC
NP_001285717.1
NP_001285718.1
NP_609149.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7786160..7790557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298788.1 → NP_001285717.1  uncharacterized protein Dmel_CG7149, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9T3
    Conserved Domains (1) summary
    cl00453
    Location:4 → 390
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. NM_001298789.1 → NP_001285718.1  uncharacterized protein Dmel_CG7149, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0S3, Q9VLX1
    Conserved Domains (1) summary
    cl00453
    Location:4 → 389
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. NM_135305.4 → NP_609149.3  uncharacterized protein Dmel_CG7149, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609149.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0S3, Q9VLX1
    Related
    FBpp0079119
    Conserved Domains (1) summary
    cl00453
    Location:4 → 389
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T0S3 Q8T0S3
X2J9T3 X2J9T3

Gene LinkOut

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