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LIPM lipase family member M [ Homo sapiens (human) ]

Gene ID: 340654, updated on 10-Dec-2024

Summary

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Official Symbol
LIPMprovided by HGNC
Official Full Name
lipase family member Mprovided by HGNC
Primary source
HGNC:HGNC:23455
See related
Ensembl:ENSG00000173239 MIM:613923; AllianceGenome:HGNC:23455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL3; bA304I5.1
Summary
Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in skin (RPKM 5.3), stomach (RPKM 0.7) and 2 other tissues See more
Orthologs
all
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Genomic context

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See LIPM in Genome Data Viewer
Location:
10q23.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88802730..88820546)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89686676..89704478)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90562487..90580303)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:90518932-90520131 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3725 Neighboring gene ankyrin repeat domain 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3726 Neighboring gene uncharacterized LOC124902551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2589 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene STAM binding protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Large-scale identification of human genes implicated in epidermal barrier function. Toulza E, et al. Genome Biol, 2007. PMID 17562024, Free PMC Article
  2. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipoprotein lipase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cornification TAS
Traceable Author Statement
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
lipase member M
Names
lipase M
lipase-like abhydrolase domain-containing protein 3
lipase-like, ab-hydrolase domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128215.1 → NP_001121687.1  lipase member M precursor

    See identical proteins and their annotated locations for NP_001121687.1

    Status: VALIDATED

    Source sequence(s)
    AL358532, BC157888, EF426484
    Consensus CDS
    CCDS44457.1
    UniProtKB/Swiss-Prot
    A6PVS3, B2RXK7, B5MCR3, Q5VYY2
    Related
    ENSP00000383901.3, ENST00000404743.9
    Conserved Domains (3) summary
    pfam00561
    Location:92 → 392
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:49 → 111
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:93 → 231
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88802730..88820546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539748.4 → XP_011538050.1  lipase member M isoform X1

    See identical proteins and their annotated locations for XP_011538050.1

    Conserved Domains (3) summary
    pfam00561
    Location:92 → 399
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:49 → 111
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:93 → 231
    Abhydrolase_5; Alpha/beta hydrolase family

  2. XM_011539751.4 → XP_011538053.1  lipase member M isoform X2

    Conserved Domains (1) summary
    PLN02872
    Location:1 → 283
    PLN02872; triacylglycerol lipase

  3. XM_011539752.4 → XP_011538054.1  lipase member M isoform X3

    Conserved Domains (1) summary
    PLN02872
    Location:1 → 221
    PLN02872; triacylglycerol lipase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89686676..89704478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365721.1 → XP_054221696.1  lipase member M isoform X1

  2. XM_054365722.1 → XP_054221697.1  lipase member M isoform X2

  3. XM_054365723.1 → XP_054221698.1  lipase member M isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VYY2.2 GenPept UniProtKB/Swiss-Prot:Q5VYY2

Gene LinkOut

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