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Trf - TBP-related factor

Enables cis-regulatory region sequence-specific DNA binding activity and general transcription initiation factor binding activity. Contributes to RNA polymerase II general transcription initiation factor activity and core promoter sequence-specific DNA binding activity. Involved in tRNA transcription by RNA polymerase III; transcription initiation at RNA polymerase II promoter; and transcription initiation at RNA polymerase III promoter. Located in nucleus and polytene chromosome. Part of transcription regulator complex. Is expressed in organism; presumptive embryonic/larval central nervous system; spermatocyte; supraesophageal ganglion; and testis. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Trf

NCBI Orthologs

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Species Gene Architecture aa