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CG8419 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34118, updated on 4-Jan-2025

Summary

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Official Symbol
CG8419provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031999
Locus tag
Dmel_CG8419
See related
AllianceGenome:FB:FBgn0031999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8419
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Is expressed in spermatozoon. Orthologous to human TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG8419 in Genome Data Viewer
Location:
28F1-28F2; 2-30 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8206171..8209637)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8206171..8209637)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121 Neighboring gene Suppressor of variegation 205 Neighboring gene Single stranded-binding protein c31A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Origin and diversification of TRIM ubiquitin ligases. Marín I. PLoS One, 2012. PMID 23185523, Free PMC Article
  2. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. Sardiello M, et al. BMC Evol Biol, 2008 Aug 1. PMID 18673550, Free PMC Article
  3. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
  4. Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. Milchanowski AB, et al. Genetics, 2004 Sep. PMID 15454546, Free PMC Article
  5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8419-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8206171..8209637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135349.3 → NP_609193.1  uncharacterized protein Dmel_CG8419 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609193.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3ZAM2, Q9VLR7
    Related
    FBpp0079210
    Conserved Domains (5) summary
    smart00184
    Location:308 → 334
    RING; Ring finger
    smart00557
    Location:751 → 849
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:748 → 846
    Filamin; Filamin/ABP280 repeat
    pfam00643
    Location:537 → 576
    zf-B_box; B-box zinc finger
    cl23765
    Location:583 → 703
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLR7 Q9VLR7

Gene LinkOut

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