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Ostgamma Oligosaccharide transferase gamma subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34137, updated on 9-Dec-2024

Summary

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Official Symbol
Ostgammaprovided by FlyBase
Official Full Name
Oligosaccharide transferase gamma subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0032015
Locus tag
Dmel_CG7830
See related
AllianceGenome:FB:FBgn0032015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7830; dMagT1; Dmel\CG7830; MagT1; OST
Summary
Involved in cell migration; encapsulation of foreign target; and magnesium ion transmembrane transport. Located in cytoplasm and endomembrane system. Is expressed in adult head; adult heart; and organism. Used to study prostate cancer. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; autosomal recessive intellectual developmental disorder 7; and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1) and TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ostgamma in Genome Data Viewer
Location:
29A3-29A3; 2-31 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8306696..8308192, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8306696..8308192, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene wollknaeuel Neighboring gene Sarcoglycan alpha Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitoshell

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila MagT1 is upregulated by PKC activation. Hu Y, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23727583
  2. MagT1 is essential for Drosophila development through the shaping of Wingless and Decapentaplegic signaling pathways. Xun Q, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29959918
  3. Genetic human prion disease modelled in PrP transgenic Drosophila. Thackray AM, et al. Biochem J, 2017 Sep 20. PMID 28814578, Free PMC Article
  4. Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Xie Q, et al. Neuron, 2022 Jul 20. PMID 35613619, Free PMC Article
  5. Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. Mortimer NT, et al. PLoS Pathog, 2012. PMID 22829770, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endomembrane system HDA PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oligosaccharide transferase gamma subunit
Names
CG7830-PA
Ostgamma-PA
magnesium transporter subtype 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8306696..8308192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135360.4 → NP_609204.2  oligosaccharide transferase gamma subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609204.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY53, Q9VLP8
    Related
    FBpp0079233
    Conserved Domains (1) summary
    pfam04756
    Location:164 → 312
    OST3_OST6; OST3 / OST6 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SY53 Q8SY53

Gene LinkOut

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