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Agpat2 1-Acylglycerol-3-phosphate O-acyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34176, updated on 9-Dec-2024

Summary

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Official Symbol
Agpat2provided by FlyBase
Official Full Name
1-Acylglycerol-3-phosphate O-acyltransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0026718
Locus tag
Dmel_CG17608
See related
AllianceGenome:FB:FBgn0026718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AGPAT; AGPAT1; AGPAT2; CG17608; dAGPAT2; DmAGPAT1/2; Dmel\CG17608; fu12
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in behavioral response to ethanol. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Agpat2 in Genome Data Viewer
Location:
29C5-29D1; 2-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8449691..8463994, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8449691..8463994, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Aminoadipate-semialdehyde dehydrogenase Neighboring gene piragua Neighboring gene dachs Neighboring gene Chemosensory protein A 29a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. Castorena KM, et al. BMC Genomics, 2010 Mar 17. PMID 20236518, Free PMC Article
  2. Late-life shift in caloric intake affects fly metabolism and longevity. Li M, et al. Proc Natl Acad Sci U S A, 2023 Dec 12. PMID 38064506, Free PMC Article
  3. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Pagac M, et al. Cell Rep, 2016 Nov 1. PMID 27806294, Free PMC Article
  4. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. Tian Y, et al. PLoS Genet, 2011 Apr. PMID 21533227, Free PMC Article
  5. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-Acylglycerol-3-phosphate O-acyltransferase 2
Names
Agpat2-PA
Agpat2-PB
Agpat2-PC
Agpat2-PD
CG17608-PA
CG17608-PB
CG17608-PC
CG17608-PD
fu12
NP_001162912.1
NP_001285755.1
NP_609231.2
NP_723398.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8449691..8463994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135387.4 → NP_609231.2  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609231.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTI0, Q8T9K7
    Related
    FBpp0079310
    Conserved Domains (1) summary
    cd07989
    Location:65 → 248
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  2. NM_001169441.2 → NP_001162912.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTI0, Q8T9K7
    Conserved Domains (1) summary
    cd07989
    Location:65 → 248
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  3. NM_001298826.1 → NP_001285755.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTI0, Q8T9K7
    Conserved Domains (1) summary
    cd07989
    Location:65 → 248
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  4. NM_164823.3 → NP_723398.1  1-Acylglycerol-3-phosphate O-acyltransferase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTI0, Q8T9K7
    Conserved Domains (1) summary
    cd07989
    Location:65 → 248
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTI0 Q7KTI0
Q8T9K7 Q8T9K7

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