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LManIV Lysosomal alpha-mannosidase IV [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34204, updated on 4-Jan-2025

Summary

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Official Symbol
LManIVprovided by FlyBase
Official Full Name
Lysosomal alpha-mannosidase IVprovided by FlyBase
Primary source
FLYBASE:FBgn0032067
Locus tag
Dmel_CG9465
See related
AllianceGenome:FB:FBgn0032067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9465; Dmel\CG9465
Summary
Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See LManIV in Genome Data Viewer
Location:
29F1-29F1; 2-34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8769159..8772344, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8769159..8772344, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lysosomal alpha-mannosidase III Neighboring gene Lysosomal alpha-mannosidase V Neighboring gene Lysosomal alpha-mannosidase VI

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
  2. Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. Yang H, et al. BMC Genomics, 2017 May 18. PMID 28521739, Free PMC Article
  3. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
  4. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
  5. Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Chng WA, et al. Cell Rep, 2014 Oct 9. PMID 25284780

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysosomal alpha-mannosidase IV
Names
CG9465-PB
LManIV-PB
NP_609251.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8769159..8772344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135407.3 → NP_609251.2  lysosomal alpha-mannosidase IV [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609251.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLI1
    Conserved Domains (3) summary
    cd10810
    Location:39 → 312
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:359 → 434
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:483 → 973
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLI1 Q9VLI1

Gene LinkOut

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