Aldh - Aldehyde dehydrogenase

Enables acetaldehyde dehydrogenase (acetylating) activity and aldehyde dehydrogenase (NAD+) activity. Involved in acetaldehyde metabolic process and response to ethanol. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; anterior endoderm; endoderm anlage; and gut section. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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