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FucTB alpha1,3-fucosyltransferase B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34260, updated on 4-Jan-2025

Summary

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Official Symbol
FucTBprovided by FlyBase
Official Full Name
alpha1,3-fucosyltransferase Bprovided by FlyBase
Primary source
FLYBASE:FBgn0032117
Locus tag
Dmel_CG4435
See related
AllianceGenome:FB:FBgn0032117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4435; CT14430; Dmel\CG4435
Summary
Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in Golgi membrane. Is expressed in adult head; head mesoderm; organism; and trunk mesoderm. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to several human genes including FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See FucTB in Genome Data Viewer
Location:
30B3-30B3; 2-35 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9428669..9431052, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9428669..9431052, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Multicopper oxidase 1 Neighboring gene Fat body protein 2 Neighboring gene uncharacterized protein Neighboring gene scattered Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S28-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope. Fabini G, et al. J Biol Chem, 2001 Jul 27. PMID 11382750
  2. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. Rendic D, et al. J Biol Chem, 2006 Feb 10. PMID 16314421
  3. Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Rendić D, et al. Glycobiology, 2010 Nov. PMID 20688784, Free PMC Article
  4. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307
  5. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha1,3-fucosyltransferase B
Names
CG4435-PA
CG4435-PC
CG4435-PD
FucTB-PA
FucTB-PC
FucTB-PD
alpha1,3-fucosyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9428669..9431052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298850.1 → NP_001285779.1  alpha1,3-fucosyltransferase B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4QQB0, Q8I928, Q9VLC1
    UniProtKB/TrEMBL
    X2J5D8
    Conserved Domains (2) summary
    pfam00852
    Location:178 → 314
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:61 → 139
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. NM_135444.5 → NP_609288.4  alpha1,3-fucosyltransferase B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609288.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4QQB0, Q8I928, Q9VLC1
    UniProtKB/TrEMBL
    X2J5D8
    Conserved Domains (2) summary
    pfam00852
    Location:178 → 314
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:61 → 139
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. NM_001298851.1 → NP_001285780.1  alpha1,3-fucosyltransferase B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9EQY2
    Conserved Domains (1) summary
    pfam00852
    Location:2 → 77
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EQY2 B9EQY2
Q9VLC1.2 Q9VLC1
X2J5D8 X2J5D8

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