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ZNF284 zinc finger protein 284 [ Homo sapiens (human) ]

Gene ID: 342909, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF284provided by HGNC
Official Full Name
zinc finger protein 284provided by HGNC
Primary source
HGNC:HGNC:13078
See related
Ensembl:ENSG00000186026 AllianceGenome:HGNC:13078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF284L
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF284 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44072159..44089613)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46895045..46912496)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44576312..44593766)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene zinc finger protein 222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). Yin G, et al. Mol Biol Rep, 2006 Jun. PMID 16817023
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
  4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781F1775

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 284

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037813.4 → NP_001032902.1  zinc finger protein 284

    See identical proteins and their annotated locations for NP_001032902.1

    Status: VALIDATED

    Source sequence(s)
    AC084219, AY458845, BM989725
    Consensus CDS
    CCDS46099.1
    UniProtKB/Swiss-Prot
    Q2VY69, Q86WM1
    Related
    ENSP00000411032.2, ENST00000421176.4
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:209 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44072159..44089613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451486.2 → XP_024307254.1  zinc finger protein 284 isoform X1

    UniProtKB/Swiss-Prot
    Q2VY69, Q86WM1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:209 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011526907.4 → XP_011525209.1  zinc finger protein 284 isoform X1

    See identical proteins and their annotated locations for XP_011525209.1

    UniProtKB/Swiss-Prot
    Q2VY69, Q86WM1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:209 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_011526908.4 → XP_011525210.1  zinc finger protein 284 isoform X1

    See identical proteins and their annotated locations for XP_011525210.1

    UniProtKB/Swiss-Prot
    Q2VY69, Q86WM1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:209 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46895045..46912496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320843.1 → XP_054176818.1  zinc finger protein 284 isoform X1

  2. XM_054320842.1 → XP_054176817.1  zinc finger protein 284 isoform X1

  3. XM_054320841.1 → XP_054176816.1  zinc finger protein 284 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2VY69.1 GenPept UniProtKB/Swiss-Prot:Q2VY69

Gene LinkOut

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