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DYNLT4 dynein light chain Tctex-type 4 [ Homo sapiens (human) ]

Gene ID: 343521, updated on 10-Dec-2024

Summary

Official Symbol
DYNLT4provided by HGNC
Official Full Name
dynein light chain Tctex-type 4provided by HGNC
Primary source
HGNC:HGNC:32315
See related
Ensembl:ENSG00000188396 MIM:611713; AllianceGenome:HGNC:32315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCTEX1D4
Summary
Enables protein phosphatase 1 binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including acrosomal vesicle; cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in esophagus (RPKM 3.3), appendix (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See DYNLT4 in Genome Data Viewer
Location:
1p34.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44805893..44807351, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44677047..44678505, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45271565..45273023, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45245573-45246073 Neighboring gene ribosomal protein S15a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45251699-45252384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45252385-45253070 Neighboring gene bestrophin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45257343-45258034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45258727-45259416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45265053-45265721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45271492-45272342 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:45272786-45273985 Neighboring gene polo like kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45274044-45274893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 953 Neighboring gene BTB domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:45284771-45285427 and GRCh37_chr1:45285428-45286084 Neighboring gene RNA, U5E small nuclear 6, pseudogene Neighboring gene patched 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein light chain Tctex-type 4
Names
Tctex1 domain containing 4
Tctex2 beta
novel Tctex-1 family domain-containing protein
protein N22.1
tctex-2-beta
tctex1 domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013632.4NP_001013654.1  dynein light chain Tctex-type 4

    See identical proteins and their annotated locations for NP_001013654.1

    Status: VALIDATED

    Source sequence(s)
    AL592166, BC092499, DQ132441
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily
  2. NM_001377534.1NP_001364463.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Related
    ENSP00000341803.2, ENST00000339355.3
    Conserved Domains (1) summary
    cl41776
    Location:108221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily
  3. NM_001377535.1NP_001364464.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily
  4. NM_001377536.1NP_001364465.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    44805893..44807351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419617.1XP_047275573.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
  2. XM_047419619.1XP_047275575.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
  3. XM_047419618.1XP_047275574.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
    Related
    ENSP00000501642.1, ENST00000675259.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44677047..44678505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336368.1XP_054192343.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
  2. XM_054336369.1XP_054192344.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
  3. XM_054336370.1XP_054192345.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98