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Prosalpha6 Proteasome alpha6 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34359, updated on 9-Dec-2024

Summary

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Official Symbol
Prosalpha6provided by FlyBase
Official Full Name
Proteasome alpha6 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0250843
Locus tag
Dmel_CG4904
See related
AllianceGenome:FB:FBgn0250843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
143314_at; alpha-6; Alpha-6; alpha6; alpha_dm; anon-SAGE:Wang-116; CG4904; Dmel\CG4904; pros 35; Pros alpha6; Pros-35; PROS-35; Pros-Dm35; PROS-Dm35; pros35; Pros35; PSMA1
Summary
Involved in ventral furrow formation. Acts upstream of with a positive effect on determination of adult lifespan. Located in cytoplasm and nucleus. Part of proteasome complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; gut section; and mesoderm. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Prosalpha6 in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10221351..10222546)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10221351..10222546)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene athos Neighboring gene Niemann-Pick type C-1a Neighboring gene Bcs1 chaperone Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. Haass C, et al. EMBO J, 1989 Aug. PMID 2477245, Free PMC Article
  2. Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35. Frentzel S, et al. Eur J Biochem, 1992 May 1. PMID 1374331
  3. The Drosophila PROS-28.1 gene is a member of the proteasome gene family. Haass C, et al. Gene, 1990 Jun 15. PMID 2169443
  4. Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. Klein U, et al. J Cell Biol, 1990 Dec. PMID 2126012, Free PMC Article
  5. A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Huang X, et al. Development, 2005 Nov. PMID 16221727

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteasome alpha6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.
    Title: Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
acts_upstream_of_positive_effect determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ventral furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome alpha6 subunit
Names
20S alpha6 subunit
20s proteasome
CG4904-PA
CG4904-PB
Prosalpha6-PA
Prosalpha6-PB
alpha-subunit of 20S proteasome
alpha6
anon-SAGE:Wang-116
proteasome 35
proteasome 35 kD subunit
proteasome 35-kDa subunit
proteasome 35kD subunit
proteasome 35kDa subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10221351..10222546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298869.1 → NP_001285798.1  proteasome alpha6 subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285798.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12881, Q8SZ22, Q9VL23
    UniProtKB/TrEMBL
    I0DHK3
    Conserved Domains (2) summary
    COG0638
    Location:4 → 231
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03749
    Location:6 → 219
    proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

  2. NM_078808.4 → NP_523532.1  proteasome alpha6 subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523532.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12881, Q8SZ22, Q9VL23
    UniProtKB/TrEMBL
    I0DHK3
    Related
    FBpp0079538
    Conserved Domains (2) summary
    COG0638
    Location:4 → 231
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03749
    Location:6 → 219
    proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
I0DHK3 I0DHK3
P12881.1 P12881

Gene LinkOut

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