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Usp14 Ubiquitin specific protease 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34387, updated on 9-Dec-2024

Summary

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Official Symbol
Usp14provided by FlyBase
Official Full Name
Ubiquitin specific protease 14provided by FlyBase
Primary source
FLYBASE:FBgn0032216
Locus tag
Dmel_CG5384
See related
AllianceGenome:FB:FBgn0032216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5384; Dmel\CG5384; DmUsp14; Q9VKZ8; Ubp6p; usp14; USP14
Summary
Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Involved in protein ubiquitination. Is expressed in adult head. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Usp14 in Genome Data Viewer
Location:
31D4-31D5; 2-41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10312265..10314396, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10312265..10314396, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cdk5 activator-like protein Neighboring gene lethal (2) SH0834 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila. Rong Q, et al. J Virol, 2024 May 14. PMID 38563731, Free PMC Article
  2. Inactivation of USP14 Perturbs Ubiquitin Homeostasis and Delays the Cell Cycle in Mouse Embryonic Fibroblasts and in Fruit Fly Drosophila. Lee JH, et al. Cell Physiol Biochem, 2018. PMID 29763934
  3. Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease. Favaro M, et al. Front Neurosci, 2024. PMID 39161651, Free PMC Article
  4. The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa. Park JE, et al. Biology (Basel), 2020 Oct 12. PMID 33053617, Free PMC Article
  5. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster. Kovács L, et al. J Cell Sci, 2020 Jan 23. PMID 31974276

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila.
    Title: Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila.
  2. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster.
    Title: Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster.
  3. genetic and pharmacological inhibition of USP14 promotes mitophagy
    Title: USP14 inhibition corrects an in vivo model of impaired mitophagy.
  4. Knocking down USP14 in Drosophila resulted in delayed eye development associated with reduced mitotic activity.
    Title: Inactivation of USP14 Perturbs Ubiquitin Homeostasis and Delays the Cell Cycle in Mouse Embryonic Fibroblasts and in Fruit Fly Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin specific protease 14
Names
CG5384-PA
CG5384-PB
Usp14-PA
Usp14-PB
NP_001260321.1
NP_609377.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10312265..10314396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273392.1 → NP_001260321.1  ubiquitin specific protease 14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKZ8
    Conserved Domains (4) summary
    smart00213
    Location:4 → 73
    UBQ; Ubiquitin homologues
    cd02657
    Location:105 → 467
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:103 → 467
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:5 → 73
    UBQ; Ubiquitin-like proteins

  2. NM_135533.2 → NP_609377.1  ubiquitin specific protease 14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKZ8
    Related
    FBpp0079650
    Conserved Domains (4) summary
    smart00213
    Location:4 → 73
    UBQ; Ubiquitin homologues
    cd02657
    Location:105 → 467
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:103 → 467
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:5 → 73
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKZ8 Q9VKZ8

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