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CG4995 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34390, updated on 9-Dec-2024

Summary

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Official Symbol
CG4995provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032219
Locus tag
Dmel_CG4995
See related
AllianceGenome:FB:FBgn0032219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18626; Dmel\CG4995
Summary
Predicted to enable high-affinity L-arginine transmembrane transporter activity and high-affinity lysine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4995 in Genome Data Viewer
Location:
31D7-31D8; 2-41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10322476..10324990)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10322476..10324990)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonucleoside diphosphate reductase large subunit Neighboring gene Schwannomin interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
  2. Differential amino acid transporter expression in adult Drosophila melanogaster tissues. Wright Y, et al. MicroPubl Biol, 2024. PMID 38481556, Free PMC Article
  3. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
  4. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
  5. Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures in Drosophila. Bossen J, et al. Int J Mol Sci, 2023 Mar 15. PMID 36982710, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables high-affinity L-arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high-affinity lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4995-PA
CG4995-PB
CG4995-PC
CG4995-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10322476..10324990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164914.2 → NP_723564.1  uncharacterized protein Dmel_CG4995, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723564.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IH44, Q9VKZ4, Q9VKZ5
    Related
    FBpp0079579
    Conserved Domains (2) summary
    PTZ00169
    Location:41 → 295
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:128 → 218
    Mito_carr; Mitochondrial carrier protein

  2. NM_135536.3 → NP_609380.1  uncharacterized protein Dmel_CG4995, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609380.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IH44, Q9VKZ4, Q9VKZ5
    Related
    FBpp0079580
    Conserved Domains (2) summary
    PTZ00169
    Location:41 → 295
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:128 → 218
    Mito_carr; Mitochondrial carrier protein

  3. NM_164915.2 → NP_723565.1  uncharacterized protein Dmel_CG4995, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q76NQ2, Q8IH44
    Related
    FBpp0079581
    Conserved Domains (2) summary
    PTZ00169
    Location:2 → 256
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:89 → 179
    Mito_carr; Mitochondrial carrier protein

  4. NM_001273396.1 → NP_001260325.1  uncharacterized protein Dmel_CG4995, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q76NQ2, Q8IH44
    Conserved Domains (2) summary
    PTZ00169
    Location:2 → 256
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:89 → 179
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76NQ2 Q76NQ2
Q8IH44 Q8IH44
Q9VKZ5 Q9VKZ5

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