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pim pimples [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34404, updated on 9-Dec-2024

Summary

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Official Symbol
pimprovided by FlyBase
Official Full Name
pimplesprovided by FlyBase
Primary source
FLYBASE:FBgn0003087
Locus tag
Dmel_CG5052
See related
AllianceGenome:FB:FBgn0003087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5052; Dmel\CG5052; frag2; l(2)31Df; Pim; PIM; sec
Summary
Involved in digestive tract development; gonad development; and mitotic sister chromatid separation. Located in cytoplasm. Is expressed in several structures, including central brain primordium; ganglia; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See pim in Genome Data Viewer
Location:
31D10-31D10; 2-41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10362989..10364092)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10362989..10364092)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Caseinolytic protease proteolytic subunit Neighboring gene Cullin-associated and neddylation-dissociated 1 Neighboring gene lowfat Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The making and breaking of sister chromatid cohesion. Cohen-Fix O. Cell, 2001 Jul 27. PMID 11511341
  2. Separase: a conserved protease separating more than just sisters. Ross KE, et al. Trends Cell Biol, 2002 Jan. PMID 11853993
  3. Chromosome changes in cell differentiation. Miller OJ. Genetics, 1997 May. PMID 9135996, Free PMC Article
  4. Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila. Guo Z, et al. J Cell Sci, 2016 Feb 1. PMID 26675236
  5. Sister chromatid cohesion in mitosis. Biggins S, et al. Curr Opin Genet Dev, 1999 Apr. PMID 10322145

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effects of the stabilized securin PIM with mutations in the D-box are enhanced in vivo by reduced Polo kinase function or by mitotically stabilized Cyclin A.
    Title: Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in digestive tract mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pimples
Names
CG5052-PA
CG5052-PB
PIMPLES
fragmented gonads 2
pim-PA
pim-PB
securin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10362989..10364092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273405.1 → NP_001260334.1  pimples, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260334.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24454
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 188
    Securin; Securin sister-chromatid separation inhibitor

  2. NM_057330.3 → NP_476678.1  pimples, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476678.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24454
    Related
    FBpp0079591
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 188
    Securin; Securin sister-chromatid separation inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24454 Q24454

Gene LinkOut

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