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STUB1 - STIP1 homology and U-box containing protein 1

Enables ubiquitin protein ligase activity. Involved in negative regulation of insulin receptor signaling pathway; positive regulation of proteolysis; and protein ubiquitination. Predicted to be active in Z disc. Is expressed in adult head; eye; and organism. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa