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Lrr47 Leucine-rich repeat 47 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34449, updated on 9-Dec-2024

Summary

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Official Symbol
Lrr47provided by FlyBase
Official Full Name
Leucine-rich repeat 47provided by FlyBase
Primary source
FLYBASE:FBgn0010398
Locus tag
Dmel_CG6098
See related
AllianceGenome:FB:FBgn0010398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6098; CT19173; Dmel\CG6098; Lrr-47; LRR47
Summary
Predicted to be involved in Ras protein signal transduction. Located in cytoplasm and nucleus. Is expressed in organism. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Lrr47 in Genome Data Viewer
Location:
31F5-31F5; 2-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10517335..10519269)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10517335..10519269)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid transport protein 1 Neighboring gene Lipase 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of Drosophila. Ntwasa M, et al. Biochim Biophys Acta, 1994 Jun 21. PMID 8018718
  2. The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo. Gubala AM, et al. Mol Biol Evol, 2017 May 1. PMID 28104747, Free PMC Article
  3. Promoter sequence and expression of the leucine-rich repeat gene LRR47: evidence for cytoplasmic and nuclear localization in Drosophila embryos and cells. Buchanan SG, et al. Gene, 1998 May 12. PMID 9602138
  4. Translational control via protein-regulated upstream open reading frames. Medenbach J, et al. Cell, 2011 Jun 10. PMID 21663794
  5. New slbo-Gal4 driver lines for the analysis of border cell migration during Drosophila oogenesis. Ogienko AA, et al. Chromosoma, 2018 Dec. PMID 30030602

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Leucine-rich repeat 47
Names
CG6098-PA
CG6098-PB
Lrr47-PA
Lrr47-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10517335..10519269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273426.1 → NP_001260355.1  Leucine-rich repeat 47, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24386, Q9VKU0
    Conserved Domains (3) summary
    sd00033
    Location:156 → 178
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:156 → 194
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:154 → 211
    LRR_8; Leucine rich repeat

  2. NM_078815.3 → NP_523539.2  Leucine-rich repeat 47, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523539.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24386, Q9VKU0
    Related
    FBpp0079681
    Conserved Domains (3) summary
    sd00033
    Location:156 → 178
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:156 → 194
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:154 → 211
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24386 Q24386
Q9VKU0 Q9VKU0

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