U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cog8 Component of oligomeric golgi complex 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34571, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Cog8provided by FlyBase
Official Full Name
Component of oligomeric golgi complex 8provided by FlyBase
Primary source
FLYBASE:FBgn0287204
Locus tag
Dmel_CG6488
See related
AllianceGenome:FB:FBgn0287204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6488; COG8; Dmel\CG6488
Summary
Predicted to be involved in intra-Golgi vesicle-mediated transport. Part of Golgi transport complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIh. Orthologous to human COG8 (component of oligomeric golgi complex 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cog8 in Genome Data Viewer
Location:
32F2-32F2; 2-44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11496804..11498948, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11496804..11498948, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46454 Neighboring gene uncharacterized protein Neighboring gene spalt-adjacent Neighboring gene spatzle 4 Neighboring gene Discs large 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. Hartwig C, et al. J Neurosci, 2021 Jan 13. PMID 33208468, Free PMC Article
  2. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
  3. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
  4. The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle. Spletter ML, et al. EMBO Rep, 2015 Feb. PMID 25532219, Free PMC Article
  5. Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. Dottorini T, et al. BMC Bioinformatics, 2011 Jan 26. PMID 21269436, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Golgi transport complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
component of oligomeric golgi complex 8
Names
CG6488-PA
Cog8-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11496804..11498948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135659.3 → NP_609503.2  component of oligomeric golgi complex 8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609503.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNB2, Q8T9C7, Q9VKH0
    Related
    FBpp0079833
    Conserved Domains (1) summary
    pfam04124
    Location:37 → 379
    Dor1; Dor1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKH0.1 Q9VKH0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous