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Wdr81 WD repeat domain 81 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34616, updated on 4-Jan-2025

Summary

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Official Symbol
Wdr81provided by FlyBase
Official Full Name
WD repeat domain 81provided by FlyBase
Primary source
FLYBASE:FBgn0032395
Locus tag
Dmel_CG6734
See related
AllianceGenome:FB:FBgn0032395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6734; CG6734; Dmel\CG6734; dWDR81
Summary
Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in positive regulation of mitotic cell cycle phase transition. Predicted to be located in cytosol and early endosome membrane. Predicted to be active in early endosome and late endosome. Used to study microcephaly. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Wdr81 in Genome Data Viewer
Location:
33B8-33B9; 2-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12014304..12020960, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12014304..12020960, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rhodopsin 5 Neighboring gene long non-coding RNA:CR44588 Neighboring gene long non-coding RNA:CR44587 Neighboring gene Dietary and metabolic glutamate transporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells. Cavallin M, et al. Brain, 2017 Oct 1. PMID 28969387
  2. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF. Jensen LT, et al. Cell Stress Chaperones, 2008 Summer. PMID 18759003, Free PMC Article
  3. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
  4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat domain 81
Names
CG6734-PA
Wdr81-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12014304..12020960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135691.2 → NP_609535.1  WD repeat domain 81 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKD0
    Related
    FBpp0079896
    Conserved Domains (4) summary
    cd06071
    Location:345 → 588
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:1644 → 1877
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1662 → 1705
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1651 → 1876
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKD0 Q9VKD0

Gene LinkOut

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