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JhI-21 Juvenile hormone Inducible-21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34624, updated on 9-Dec-2024

Summary

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Official Symbol
JhI-21provided by FlyBase
Official Full Name
Juvenile hormone Inducible-21provided by FlyBase
Primary source
FLYBASE:FBgn0028425
Locus tag
Dmel_CG12317
See related
AllianceGenome:FB:FBgn0028425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12317; Dmel\CG12317; JHI-21; jhl-21; Jhl-21
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Involved in several processes, including L-leucine import across plasma membrane; cellular response to L-leucine; and positive regulation of insulin secretion. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic/larval motor neurons; embryonic/larval neuromuscular junction; ganglia; and larval central nervous system. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See JhI-21 in Genome Data Viewer
Location:
33B11-33C1; 2-46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12051755..12056042, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12051755..12056042, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44589 Neighboring gene Promyelocytic leukemia zinc finger Neighboring gene Phosphatidylinositol-specific phospholipase C X domain containing Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein Neighboring gene Rab3 GTPase activating protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hemolymph amino acid variations following behavioral and genetic changes in individual Drosophila larvae. Piyankarage SC, et al. Amino Acids, 2010 Mar. PMID 19360460
  2. JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport. Ziegler AB, et al. Sci Rep, 2018 Jan 30. PMID 29382949, Free PMC Article
  3. Juvenile hormone signaling during oogenesis in Drosophila melanogaster. Dubrovsky EB, et al. Insect Biochem Mol Biol, 2002 Nov. PMID 12530223
  4. Hormonal regulation and functional role of Drosophila E75A orphan nuclear receptor in the juvenile hormone signaling pathway. Dubrovsky EB, et al. Dev Biol, 2004 Apr 15. PMID 15063166
  5. Serotonin signaling mediates protein valuation and aging. Ro J, et al. Elife, 2016 Aug 23. PMID 27572262, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
    Title: JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
  2. Data show that CG2791 and two Drosophila homologues of the mammalian CD98 light chains, Mnd (Minidiscs) and JhI-21, are required for normal levels of System L transport.
    Title: Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to L-leucine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
juvenile hormone Inducible-21
Names
CG12317-PA
CG12317-PB
CG12317-PC
CG12317-PD
CG12317-PE
JhI-21-PA
JhI-21-PB
JhI-21-PC
JhI-21-PD
JhI-21-PE
solute carrier 7-family amino acid transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12051755..12056042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298935.1 → NP_001285864.1  juvenile hormone Inducible-21, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKC2
    Conserved Domains (1) summary
    cl26159
    Location:27 → 494
    AA_permease_2; Amino acid permease

  2. NM_135698.4 → NP_609542.1  juvenile hormone Inducible-21, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKC2
    Related
    FBpp0088598
    Conserved Domains (1) summary
    cl26159
    Location:27 → 494
    AA_permease_2; Amino acid permease

  3. NM_164988.4 → NP_723717.2  juvenile hormone Inducible-21, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723717.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKC2
    Related
    FBpp0088925
    Conserved Domains (1) summary
    cl26159
    Location:27 → 494
    AA_permease_2; Amino acid permease

  4. NM_001298934.1 → NP_001285863.1  juvenile hormone Inducible-21, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285863.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKC2
    Conserved Domains (1) summary
    cl26159
    Location:27 → 494
    AA_permease_2; Amino acid permease

  5. NM_001259067.1 → NP_001245996.1  juvenile hormone Inducible-21, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245996.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKC2
    Conserved Domains (1) summary
    cl26159
    Location:27 → 494
    AA_permease_2; Amino acid permease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKC2 Q9VKC2

Gene LinkOut

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