Mt2 Methyltransferase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mt2provided by FlyBase
Official Full Name: Methyltransferase 2provided by FlyBase
Primary source: FLYBASE:FBgn0028707
Locus tag: Dmel_CG10692
See related: AllianceGenome:FB:FBgn0028707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10692; dDNMT; dDnmt2; dDNMT2; Dmel\CG10692; DmMT2; Dnmt; DNMT; dnmt2; Dnmt2; DNMT2; nmt2
Summary: Enables DNA (cytosine-5-)-methyltransferase activity; tRNA binding activity; and tRNA methyltransferase activity. Involved in several processes, including determination of adult lifespan; epigenetic regulation of gene expression; and regulation of defense response. Located in cytoplasmic stress granule and nucleus. Colocalizes with nuclear matrix. Is expressed in embryonic/larval salivary gland; organism; ovary; and testis. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 33C4-33C4; 2-46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12096525..12097687)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12096525..12097687)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence of Adaptive Evolution in Wolbachia-Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking.
Title: Evidence of Adaptive Evolution in Wolbachia-Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking.
mutations in two (cytosine-5) RNA methyltransferases, Dnmt2 and NSun2, impact the accumulation of mobile element-derived sequences and DNA repeat integrity in Drosophila.
Title: Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.
Wolbachia elevates D. melanogaster Mt2 expression to block Sindbis virus infection.
Title: Wolbachia elevates host methyltransferase expression to block an RNA virus early during infection.
The differences found in the electrostatic potentials may be linked with different affinities and processivity of DNMT2 for its different substrates (DNA, RNA or tRNA) and even for interactions with other proteins involved in the epigenetic mechanisms
Title: Linking epigenetic function to electrostatics: The DNMT2 structural model example.
Mt2, the fly's only candidate DNA methyltransferase, is not necessary for the observed DNA methylation.
Title: Now you see it: genome methylation makes a comeback in Drosophila.
No difference was detected in recombination rates between Dnmt2 -/- and Dnmt2 +/- flies in two euchromatic regions and one heterochromatic region across the genome.
Title: No detectable effect of the DNA methyltransferase DNMT2 on Drosophila meiotic recombination.
Though the genome of Drosophila is essentially unmethylated, it contains a 5-methylcytosine oxidase.
Title: The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: possible explanations.
Dnmt2 mutant flies accumulate increasing levels of Drosophila C virus and show activated innate immune responses.
Title: Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.
Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Title: Dnmt2-dependent methylomes lack defined DNA methylation patterns.
ytosine-5 methyltransferase DNMT2 controls retrotransposon silencing in Drosophila somatic cells.
Title: Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IC Inferred by Curator more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic programming of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methyltransferase 2

Names: CG10692-PC; CG10692-PD; DNA methyltransferase 2; DNA(5-cytosine) methyltransferase; Mt2-PC; Mt2-PD; cytosine-5 methyltransferase

NP_001036355.1

EC 2.1.1.-

EC 2.1.1.37

NP_477475.2

EC 2.1.1.-

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12096525..12097687

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042890.2 → NP_001036355.1 methyltransferase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036355.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8R4, Q8MSZ1, Q9VKB3

Conserved Domains (1) summary

cl17173
Location:3 → 342

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_058127.4 → NP_477475.2 methyltransferase 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477475.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8R4, Q8MSZ1, Q9VKB3

Conserved Domains (1) summary

cl17173
Location:3 → 342

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...