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Nepl7 Neprilysin-like 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34671, updated on 9-Dec-2024

Summary

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Official Symbol
Nepl7provided by FlyBase
Official Full Name
Neprilysin-like 7provided by FlyBase
Primary source
FLYBASE:FBgn0032442
Locus tag
Dmel_CG15485
See related
AllianceGenome:FB:FBgn0032442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15485; Dmel\CG15485
Summary
Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nepl7 in Genome Data Viewer
Location:
33F2-33F2; 2-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12667248..12669714, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12667248..12669714, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44596 Neighboring gene long non-coding RNA:CR44595 Neighboring gene nubbin Neighboring gene RNA and export factor binding protein 2 Neighboring gene POU domain protein 2 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 4 Neighboring gene Intraflagellar transport 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  2. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article
  3. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. Bland ND, et al. BMC Evol Biol, 2008 Jan 23. PMID 18215274, Free PMC Article
  4. Tumour-host interactions through the lens of Drosophila. Bilder D, et al. Nat Rev Cancer, 2021 Nov. PMID 34389815, Free PMC Article
  5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neprilysin-like 7
Names
CG15485-PA
CG15485-PB
Nepl7-PA
Nepl7-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12667248..12669714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135733.3 → NP_609577.2  Neprilysin-like 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609577.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2VEF3, Q9VK72
    Conserved Domains (2) summary
    cd08662
    Location:52 → 666
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:43 → 669
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

  2. NM_001298950.1 → NP_001285879.1  Neprilysin-like 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285879.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2VEF3, Q9VK72
    Conserved Domains (2) summary
    cd08662
    Location:52 → 666
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:43 → 669
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK72 Q9VK72

Gene LinkOut

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