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spict spichthyin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34681, updated on 9-Dec-2024

Summary

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Official Symbol
spictprovided by FlyBase
Official Full Name
spichthyinprovided by FlyBase
Primary source
FLYBASE:FBgn0032451
Locus tag
Dmel_CG12292
See related
AllianceGenome:FB:FBgn0032451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12292; Dmel\CG12292; spg6; Spict
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Involved in negative regulation of BMP signaling pathway; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of axon extension involved in regeneration. Predicted to be active in membrane. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval dorsal vessel; gut section; larval central brain; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6 and hereditary spastic paraplegia 6. Orthologous to several human genes including NIPAL1 (NIPA like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See spict in Genome Data Viewer
Location:
33F3-33F3; 2-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12704725..12706683)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12704725..12706683)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis. Chiang AC, et al. Sci Rep, 2017 Jan 10. PMID 28071722, Free PMC Article
  2. Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration. Rao K, et al. Mol Biol Cell, 2016 Nov 1. PMID 27605706, Free PMC Article
  3. The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases. Bayat V, et al. Curr Opin Neurobiol, 2011 Feb. PMID 20832291, Free PMC Article
  4. Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. Wang X, et al. Nat Neurosci, 2007 Feb. PMID 17220882, Free PMC Article
  5. Fighting fly genes. Robin C, et al. Trends Genet, 2007 Feb. PMID 17188395

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon extension involved in regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spichthyin
Names
CG12292-PA
CG12292-PB
spict-PA
spict-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12704725..12706683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135742.4 → NP_609586.1  spichthyin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK62
    Related
    FBpp0079978
    Conserved Domains (1) summary
    pfam05653
    Location:43 → 338
    Mg_trans_NIPA; Magnesium transporter NIPA

  2. NM_001273492.1 → NP_001260421.1  spichthyin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD12
    Conserved Domains (1) summary
    pfam05653
    Location:43 → 338
    Mg_trans_NIPA; Magnesium transporter NIPA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD12 M9PD12
Q9VK62 Q9VK62

Gene LinkOut

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